Evidence map›Paper›PMID 42559597›Full record

ArticleResearch in pharmaceutical sciences2026

Hajar Shabandoust, Negar Balmeh, Najaf Allahyari Fard, Sedighe Saberi, Afsaneh Yegdaneh, Seyed Mahmoud Mousavi, Zahra Alimardan, Zahra Ghayour Najafabadi, Seyed Hossein Hejazi

Abstract read
In one paragraph

Article in Research in pharmaceutical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hajar ShabandoustDepartment of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
Negar BalmehDepartment of Research and Development, Darou Giah Pars Avid Company, Science and Research Town, Isfahan, I.R. Iran.
Najaf Allahyari FardDepartment of Systems Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, I.R. Iran.
Sedighe SaberiDepartment of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
Afsaneh YegdanehDepartment of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
Seyed Mahmoud MousaviDepartment of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
Zahra AlimardanDepartment of Pharmacology, School of Medicine, Arak University of Medical Sciences, Arak, I.R. Iran.
Zahra Ghayour NajafabadiDepartment of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.
Seyed Hossein HejaziDepartment of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, I.R. Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: Leishmaniasis is a parasitic disease prevalent in subtropical and tropical regions, with limited and often toxic treatments ineffective against drug-resistant strains. This study explored 1,013 compounds from algae and corals for potential anti-leishmanial effects. Experimental approach: Three-dimensional structures of Findings/Results: Alga-utd-01 and Coral-utd-01 exhibited strong affinity for the GP63. Additionally, Alga-utd-05 and Coral-utd-02 showed the highest binding affinity to FPPS, while the top compounds for NMT were Alga-utd-14 and Coral-utd-03. Moreover, Alga-utd-05, Alga-utd-22, and Alga-utd-16 were common algal compounds interacting with all three proteins, and Coral-utd-01, Coral-utd-02, Coral-utd-03, Coral-utd-06, and Coral-utd-12 were common coral compounds. The MD results confirmed relatively stable interactions between the proposed compounds and the three important Conclusion and implications: The algae- and coral-derived compounds exhibited promising anti-parasitic and anti-inflammatory properties, warranting further experimental validation for leishmaniasis treatment.

Indexed as

FPPSGP63LeishmaniasisMolecular dynamicsNMT

Identifiers

PMID42559597
PMCPMC13441065

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.