Evidence map›Paper›PMID 42559515›Full record

ArticleCytoJournal2026

Feasibility of epidermal growth factor receptor and Kirsten rat sarcoma viral oncogene homolog mutation testing in non-plasma body fluids with low tumor cellularity using Idylla®: A proof-of-concept.

Aida Molero, Pilar Ortega De la Obra, Monica Mate, María Purificación Manzanares

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CytoJournal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Aida MoleroDepartment of Pathology, Hospital Universitario Río Hortega, Valladolid, Spain.ORCID https://orcid.org/0000-0003-0913-4083
Pilar Ortega De la ObraDepartment of Pathology, Hospital General de Segovia, Segovia, Spain.
Monica MateDepartment of Pathology, Hospital General de Segovia, Segovia, Spain.
María Purificación ManzanaresDepartment of Pathology, Hospital General de Segovia, Segovia, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This retrospective, single-center, small-sample proof-of-concept study aims to evaluate the feasibility of detecting Materials and Methods: Ten fluids were tested with the Ct Results: All cases showed concordance between fluid and FFPE results. Notably, Conclusion: This simple and rapid approach appears feasible in low tumor cellularity samples and could expand molecular testing to patients without accessible tissue. Validation in larger, multicenter cohorts is warranted.

Indexed as

Epidermal growth factor receptor mutationsIdylla® platformKirsten rat sarcoma viral oncogene homolog mutationsLiquid biopsyNon-plasma biological fluids

Identifiers

PMID42559515
PMCPMC13441440

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.