Evidence map›Paper›PMID 42559497›Full record

ArticleNature water2026

A nationwide wastewater monitoring pilot to identify legal and illegal substances and enable future substance use research.

Peter R Chai, Kaitlyn Hess, Marisa A P Donnelly, Mariana Matus

Abstract read
In one paragraph

Article in Nature water, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Peter R ChaiDepartment of Emergency Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID 0000-0003-0955-4117
Kaitlyn HessBiobot Analytics, Inc..
Marisa A P DonnellyBiobot Analytics, Inc..
Mariana MatusBiobot Analytics, Inc..ORCID 0000-0002-2880-0339

Funding

Smart Steps: A context-aware adherence intervention to improve PrEP adherence among men who have sex with men (MSM) with substance use disorderDP2DA056107 · NIDA · BRIGHAM AND WOMEN'S HOSPITAL · PI CHAI, PETER R · 2022 to 2022
$2.7M
NIDA NIH HHS DP2 DA056107
6 · The paper itself

Abstract

Wastewater-based epidemiology has been proposed as a faster, near real-time window into community substance use, but national-scale implementation in the United States has been elusive. A National Institute on Drug Abuse-funded pilot with Biobot Analytics spanning 76 sites across 41 states demonstrates that harmonized, near-real-time wastewater surveillance of opioids and adulterants is not only feasible but actionable, offering public health officials data weeks or months ahead of traditional reporting systems.

Identifiers

PMID42559497
PMCPMC13441254

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.