Evidence map›Paper›PMID 42559425›Full record

ArticleNeurology. Genetics2026

Associations of Cortical and Subcortical White Matter Morphometric Abnormalities With Clinical and Genetic Findings in

Matteo Lenge, Alice Dainelli, Simona Balestrini, Simona Fiori, Davide Mei, Valerio Conti, Letizia Macconi, Lucy Helena Coulter, Amy L Schneider, Antonio Napolitano and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Matteo LengeNeuroscience and Human Genetics Department, Meyer Children's Hospital IRCCS, Florence, Italy.ORCID https://orcid.org/0000-0003-2848-621X
Alice DainelliNeuroscience and Human Genetics Department, Meyer Children's Hospital IRCCS, Florence, Italy.ORCID https://orcid.org/0000-0002-5876-3508
Simona BalestriniNeuroscience and Human Genetics Department, Meyer Children's Hospital IRCCS, Florence, Italy.ORCID https://orcid.org/0000-0001-5639-1969
Simona FioriNeuroscience and Human Genetics Department, Meyer Children's Hospital IRCCS, Florence, Italy.ORCID https://orcid.org/0000-0002-0933-6120
Davide MeiNeuroscience and Human Genetics Department, Meyer Children's Hospital IRCCS, Florence, Italy.ORCID https://orcid.org/0000-0001-6790-6251
Valerio ContiNeuroscience and Human Genetics Department, Meyer Children's Hospital IRCCS, Florence, Italy.ORCID https://orcid.org/0000-0002-8326-6378
Letizia MacconiNeuroscience and Human Genetics Department, Meyer Children's Hospital IRCCS, Florence, Italy.ORCID https://orcid.org/0000-0003-3922-8486
Lucy Helena CoulterEpilepsy Research Centre, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia.ORCID https://orcid.org/0009-0007-9608-1907
Amy L SchneiderEpilepsy Research Centre, Department of Medicine, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia.ORCID https://orcid.org/0000-0001-5260-7187
Antonio NapolitanoMedical Physics Department, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.ORCID https://orcid.org/0000-0003-3258-6846
Daniela LongoDiagnostic and Interventional Neuroradiology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.ORCID https://orcid.org/0000-0002-0097-736X
Maria Camilla Rossi-EspagnetDiagnostic and Interventional Neuroradiology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Jacopo ProiettiChild Neuropsychiatry Unit, Department of Engineering for Innovation Medicine, University of Verona, Italy.ORCID https://orcid.org/0000-0002-5584-4724
Guja AstreaIRCCS Stella Maris Foundation, Pisa, Italy.ORCID https://orcid.org/0000-0001-8588-0323
Marina TrivisanoNeurology, Epilepsy and Movement Disorders Unit, Bambino Gesù Children's Hospital, IRCCS, Full Member of European Reference Network EpiCARE, Rome, Italy.ORCID https://orcid.org/0000-0002-9841-8581
Ludovico D'IncertiNeuroscience and Human Genetics Department, Meyer Children's Hospital IRCCS, Florence, Italy.ORCID https://orcid.org/0000-0002-4092-9290
Anna Maria BuccolieroNeuroscience and Human Genetics Department, Meyer Children's Hospital IRCCS, Florence, Italy.ORCID https://orcid.org/0000-0002-4993-0765
Francesca DarraChild Neuropsychiatry Unit, AOUI of Verona, Department of Engineering for Innovation Medicine, University of Verona, Full Member of European Reference Network EpiCARE, Verona, Italy.ORCID https://orcid.org/0000-0002-1062-8438
Bernardo Dalla BernardinaResearch Center for Pediatric Epilepsies (CREP), AOUI of Verona, Italy.ORCID https://orcid.org/0000-0002-8740-4686
Nicola SpecchioNeurology, Epilepsy and Movement Disorders Unit, Bambino Gesù Children's Hospital, IRCCS, Full Member of European Reference Network EpiCARE, Rome, Italy.ORCID https://orcid.org/0000-0002-8120-0287
Ingrid E SchefferDepartment of Paediatrics, University of Melbourne, Royal Children's Hospital, Melbourne, Australia; and.ORCID https://orcid.org/0000-0002-2311-2174
Renzo GuerriniNeuroscience and Human Genetics Department, Meyer Children's Hospital IRCCS, Florence, Italy.ORCID https://orcid.org/0000-0002-7272-7079

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: Disease-causing variants in the syntaxin-binding protein 1 ( Methods: We used quantitative MRI methods to estimate abnormal brain properties of the cortical mantle and volume of subcortical structures in patients with Results: Our analysis included 24 patients and 48 controls and revealed widespread cortical thickening, reduced frontal and occipital surface area, and reduced white matter (left/right hemisphere Discussion: The altered cortical patterns and WM reductions we observed in

Identifiers

PMID42559425
PMCPMC13441333

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.