ArticleAfrican journal of thoracic and critical care medicine2026
The profile of pleural effusions in oncological patients referred to the cardiothoracic surgery department in a tertiary hospital in Pretoria, South Africa: A retrospective study.
Article in African journal of thoracic and critical care medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The presence of a pleural effusion in any oncological patient (patient with known underlying current or previous malignancy) tends to be classified as advanced disease with few curative measures. Objectives: To establish the aetiology of pleural effusions in oncological patients in our subpopulation. The primary objective was to determine the percentage of proven malignant pleural effusions (MPEs). Secondary objectives were to determine the causes of proven MPEs and proven benign (non-malignant) pleural effusions (non-MPEs), and to determine whether proven non-MPEs change the initial cancer staging of patients. Methods: This was a retrospective record review of oncological patients admitted with suspected MPE to the Steve Biko Academic Hospital Cardiothoracic Surgery Unit during the period January 2018 - June 2020. Results: Ninety-one patients met the inclusion criteria. The median (interquartile range) age was 56 (41 - 66) years, and there were 54 females (59.3%) and 37 males (40.7%). Pleural biopsy results confirmed MPE in 80.2% (95% confidence interval 70.6 - 87.8) of cases (n=73/91) and non-MPE in 19.8% (n=18/91). The aetiologies of MPEs in descending order were breast (42.5%), lung (24.7%), genitourinary tract (15.1%), lymphoma (9.6%), other (6.8%) and gastrointestinal tract (1.4%) carcinomas. The aetiologies of the non-MPEs were inflammatory (88.9%) and infective (11.1%) in nature. Among the proven non-MPEs, the results led to a possible cancer downstaging in 6/18 patients (33.3%). Conclusion: Among oncological patients with pleural effusions referred to our unit, a statistically significant proportion (80.2%) had MPE by pleural tissue confirmation, with breast carcinoma being the most common cause. Of those with proven non-MPE, only a third had a possible cancer downstaging. Study synopsis:
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