ReviewIndian journal of thoracic and cardiovascular surgery2026
Comparative outcomes of anticoagulant versus antiplatelet therapy in coronary endarterectomy: a meta-analysis.
Review in Indian journal of thoracic and cardiovascular surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: Coronary endarterectomy (CE) has recently returned to the limelight due to its advantages in achieving full revascularization in very complex cases. However, to date, there are no guidelines concerning the use of postoperative antiplatelet and anticoagulant therapy (ACT). Aim: In light of this, the present meta-analysis aimed to compare the impact of ACT versus antiplatelet therapy on short- and long-term outcomes after CE. Methods: PubMed, Embase, and Medline databases were searched without any restriction on the year or the language. Two reviewers screened the studies in two rounds in a blinded manner and extracted the data into an Excel spreadsheet. The third reviewer reconciled discrepancies. Results: Nineteen studies made our final selection. Short- and long-term mortality was similar between patients treated with ACT and those receiving double antiplatelet therapy (DAPT) ( Conclusion: Postoperative mortality seems to be not affected by the anticoagulant/antiplatelet therapy after CE. DAPT leads to a greater reduction in short-term MI rates; thus, the postoperative use of DAPT seems to offer more benefits compared to ACT therapy. Long-term MI events, however, were comparable. Long-term graft patency analysis of DAPT with aspirin + clopidogrel and aspirin + ticagrelor has not revealed any superiority. Graphical abstract: Supplementary Information: The online version contains supplementary material available at 10.1007/s12055-026-02221-9.
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