Evidence map›Paper›PMID 42559083›Full record

ArticleHealth science reports2026

Increased Risk of Infections and Mortality Following Fractures in Multiple Myeloma: A Nationwide Population-Based Retrospective Cohort Study.

Ching-Chi Lee, Wei-Yi Huang, Yu-Fen Chen, I-Szu Cheng, Kuo-Yuan Huang

Abstract read
In one paragraph

Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ching-Chi LeeCollege of Medicine, Center of Clinical Medical Research, National Cheng Kung University Hospital National Cheng Kung University Tainan Taiwan.
Wei-Yi HuangInstitute of Health and Welfare Policy National Yang Ming Chiao Tung University Taipei Taiwan.
Yu-Fen ChenDepartment of Healthcare Management Yuanpei University of Medical Technology Hsinchu Taiwan.
I-Szu ChengDepartment of Family Medicine, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University Tainan Taiwan.
Kuo-Yuan HuangDepartment of Orthopedics, National Cheng Kung University Hospital, College of Medicine National Cheng Kung University Tainan Taiwan.ORCID https://orcid.org/0000-0003-2153-5664

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Aims: To determine whether patients with MM face higher risks of hospitalized infections and long-term all-cause mortality after a first fracture than non-MM fracture patients at the population level. Methods: We performed a nationwide retrospective cohort study using Taiwan National Health Insurance Research Database from 2001 to 2019. Adults with MM and non-MM adults with an index hospitalized fracture were identified and matched 1:10 by propensity scores. Cox proportional-hazards models and Kaplan-Meier analyses compared risks of lower respiratory tract, reproductive or urinary tract, intra-abdominal, and skin and soft-tissue infections requiring hospitalization, as well as all-cause mortality. Results: During 2001-2019, the incidence and age-standardized incidence of MM in Taiwan were 6.0 and 5.4 per 100,000 people, respectively, and both increased over time. After propensity-score matching, 303 MM patients with a first hospitalized fracture were compared with 3,030 non-MM fracture patients. Compared with matched non-MM patients, MM patients had significantly higher risks of lower respiratory tract infections (adjusted hazard ratio [AHR] = 2.12, 95% confidence interval [CI]: 1.72-2.61; Conclusion: MM was associated with substantially higher risks of serious infections and death after fracture. These findings support early multidisciplinary post-fracture care, including infection surveillance and prevention, in MM patients.

Indexed as

fracturesinfectionsmortalitymultiple myelomaNational Health Insurance Research Database (NHIRD)

Identifiers

PMID42559083
PMCPMC13438894

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