ReviewFrontiers in medicine2026
Injection lipolysis in aesthetic medicine: mechanisms, clinical safety, and clinical applications.
Review in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
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Abstract
Background: Injection lipolysis is increasingly used as a minimally invasive option for focal fat reduction. However, systematic data on its safety and efficacy remain limited. Objective: This review summarizes the development, mechanism, clinical application, complication management, and future directions of injection lipolysis, grounded in the anatomy of facial and cervical fat. Methods: We searched PubMed for literature published between 1943 and 2026 to trace the research history of lipolytic agents. Results: Deoxycholic acid preferentially disrupts adipocytes and exerts cytolytic effects with relative tissue selectivity. The submental fat pad is the best-documented indication. Poor injection technique can lead to skin necrosis, marginal mandibular nerve palsy, and other complications. Conclusion: Injection lipolysis is an effective tool for spot fat reduction, but its safety depends heavily on anatomical knowledge, patient selection, and strict procedural discipline. Future work should focus on precision fat reduction and further clinical validation.
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