ArticleBioinformatics and biology insights2026
Integrative Analysis of Intestinal Transcriptomes Underscores
Article in Bioinformatics and biology insights, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Intestinal transcriptomic data encompass substantial value in studying inflammatory bowel disease. By analyzing intestinal gene expression profiles, this study aimed to discover transcripts exhibiting diagnostic efficacy for IBD. Intestinal transcriptomic data from 1,458 patients with Crohn's disease (CD), 1,211 patients with ulcerative colitis (UC), and 674 healthy controls were acquired by integrating seven datasets with accession numbers GSE66407, GSE193677, GSE126124, GSE83687, GSE75214, GSE36807, and GSE16879. Then, the DEGs in IBD were analyzed by ML methods to discern transcripts that hold diagnostic power. ROC analysis identified potential biomarkers, which were subsequently tested in 16 external datasets.
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