Evidence map›Paper›PMID 42558978›Full record

ArticleDEN open2027

Delayed Argon Plasma Coagulation After Endoscopic Injection Sclerotherapy for Esophageal Varices Reduces Recurrence Risk.

Takumi Yanagita, Takuto Hikichi, Jun Nakamura, Tsunetaka Kato, Minami Hashimoto, Mitsuru Otsuka, Eisuke Kameoka, Rei Suzuki, Mitsuru Sugimoto, Hiroyuki Asama and 7 more

Abstract read
In one paragraph

Article in DEN open, 2027. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Takumi YanagitaDepartment of Endoscopy Fukushima Medical University Hospital Fukushima Japan.ORCID https://orcid.org/0000-0002-1236-857X
Takuto HikichiDepartment of Endoscopy Fukushima Medical University Hospital Fukushima Japan.ORCID https://orcid.org/0000-0002-9815-1557
Jun NakamuraDepartment of Endoscopy Fukushima Medical University Hospital Fukushima Japan.ORCID https://orcid.org/0000-0001-6006-1778
Tsunetaka KatoDepartment of Endoscopy Fukushima Medical University Hospital Fukushima Japan.ORCID https://orcid.org/0000-0002-2529-2463
Minami HashimotoDepartment of Endoscopy Fukushima Medical University Hospital Fukushima Japan.ORCID https://orcid.org/0000-0002-5750-7182
Mitsuru OtsukaDepartment of Gastroenterology Fukushima Medical University School of Medicine Fukushima Japan.ORCID https://orcid.org/0009-0001-3935-8478
Eisuke KameokaDepartment of Gastroenterology Fukushima Medical University School of Medicine Fukushima Japan.ORCID https://orcid.org/0009-0005-7517-0172
Rei SuzukiDepartment of Gastroenterology Fukushima Medical University School of Medicine Fukushima Japan.ORCID https://orcid.org/0000-0002-4049-0484
Mitsuru SugimotoDepartment of Gastroenterology Fukushima Medical University School of Medicine Fukushima Japan.ORCID https://orcid.org/0000-0002-4223-613X
Hiroyuki AsamaDepartment of Gastroenterology Fukushima Medical University School of Medicine Fukushima Japan.ORCID https://orcid.org/0000-0002-0102-0404
Hiroshi ShimizuDepartment of Gastroenterology Fukushima Medical University School of Medicine Fukushima Japan.ORCID https://orcid.org/0009-0004-9168-7561
Kento OsawaDepartment of Gastroenterology Fukushima Medical University School of Medicine Fukushima Japan.ORCID https://orcid.org/0009-0002-9846-0736
Rei OhiraDepartment of Gastroenterology Fukushima Medical University School of Medicine Fukushima Japan.ORCID https://orcid.org/0009-0001-8423-575X
Keisuke KudoDepartment of Gastroenterology Fukushima Medical University School of Medicine Fukushima Japan.ORCID https://orcid.org/0009-0000-2769-9841
Daiki NemotoDepartment of Endoscopy Fukushima Medical University Hospital Fukushima Japan.ORCID https://orcid.org/0000-0002-6812-2966
Masao KobayakawaDepartment of Endoscopy Fukushima Medical University Hospital Fukushima Japan.ORCID https://orcid.org/0000-0002-5532-7364
Hiromasa OhiraDepartment of Gastroenterology Fukushima Medical University School of Medicine Fukushima Japan.ORCID https://orcid.org/0000-0003-4331-0634

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Argon plasma coagulation (APC) is commonly used as consolidation therapy after endoscopic injection sclerotherapy (EIS) for esophageal varices (EVs); however, the optimal timing of APC remains unclear. This study evaluated the association between the EIS-APC interval and clinical outcomes. Methods: This single-center retrospective cohort study included consecutive patients receiving EIS followed by APC for EVs. Patients were categorized according to APC setting as inpatient or outpatient, which reflected differences in the EIS-APC interval. The primary outcome was cumulative variceal recurrence as analyzed using the Fine-Gray competing risk model. Secondary outcomes included ulcer persistence at the time of APC and procedure-related adverse events. Results: Among 112 patients, 82 underwent inpatient APC and 30 underwent outpatient APC. The median EIS-APC interval was 7 days and 28 days, respectively ( Conclusions: A longer EIS-APC interval was associated with a lower recurrence rate without an increase in adverse events. Delaying APC until after mucosal healing may optimize EIS treatment outcomes. Trial Registration: N/A (Only approval of the research protocol by an Institutional Review Board of Fukushima Medical University).

Indexed as

argon plasma coagulationconsolidation therapyendoscopic injection sclerotherapyesophageal varicesvariceal recurrence

Identifiers

PMID42558978
PMCPMC13439219

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.