Evidence map›Paper›PMID 42558973›Full record

ArticleExploration of targeted anti-tumor therapy2026

Transcriptional modulation of the PI3K/AKT/mTOR signaling pathway mediated by HPV16

Beatriz Eda de Oliveira Isídio, Pedro Henrique Bezerra Fontes, Gabriel Rômulo Parente da Silva, Stephanie Loureiro Leão, Bianca de França São Marcos, Isabelle Silva Simões, Elisa Fotin Genn Barros, David Beltrán Lussón, Gabriela Vitória de Araujo, Isabela Duarte de Farias and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Exploration of targeted anti-tumor therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Beatriz Eda de Oliveira IsídioLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, PE, Brazil.ORCID https://orcid.org/0009-0007-5757-5058
Pedro Henrique Bezerra FontesLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, PE, Brazil.ORCID https://orcid.org/0000-0001-5609-2977
Gabriel Rômulo Parente da SilvaLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, PE, Brazil.ORCID https://orcid.org/0009-0000-4712-4949
Stephanie Loureiro LeãoLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, PE, Brazil.ORCID https://orcid.org/0009-0000-7286-7007
Bianca de França São MarcosLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, PE, Brazil.ORCID https://orcid.org/0000-0002-8165-3534
Isabelle Silva SimõesLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, PE, Brazil.ORCID https://orcid.org/0009-0009-7121-6849
Elisa Fotin Genn BarrosLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, PE, Brazil.ORCID https://orcid.org/0009-0000-8005-2588
David Beltrán LussónLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, PE, Brazil.ORCID https://orcid.org/0009-0009-4534-4599
Gabriela Vitória de AraujoLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, PE, Brazil.ORCID https://orcid.org/0009-0006-1652-0272
Isabela Duarte de FariasLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, PE, Brazil.ORCID https://orcid.org/0009-0001-1501-4478
Karina Mayumi Tani Bezerra de MeloLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, PE, Brazil.ORCID https://orcid.org/0009-0009-2415-6337
Nathálya Lima de QueirozLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, PE, Brazil.ORCID https://orcid.org/0009-0008-0260-1543
Sandra Maria Souza da SilvaLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, PE, Brazil.
Vanessa Emanuelle Pereira SantosLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, PE, Brazil.ORCID https://orcid.org/0000-0001-9505-6119
Antonio Carlos de FreitasLaboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Federal University of Pernambuco, Recife 50670-901, PE, Brazil.ORCID https://orcid.org/0000-0002-4957-9549

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: Breast cancer is the most prevalent malignant tumor among women. Human papillomavirus (HPV) has been detected in breast tumors since the 1990s, and beyond its oncogenic potential, therapy resistance driven by viral immune evasion in non-anogenital tumors, such as oropharyngeal cancers, highlights the need to investigate viral activity in breast tissues. Among high-risk HPV types, HPV16 is one of the most prevalent and exhibits the highest carcinogenic potential. Therefore, this study aimed to evaluate the expression of HPV16 oncogenes Methods: A total of 92 breast cancer patients were included after Ethics Committee approval. Clinical data were obtained from medical records. RNA was extracted from formalin-fixed, paraffin-embedded tissues and reverse-transcribed into cDNA. Transcripts of HPV oncogenes ( Results: Forty-eight samples met RNA quality criteria and were included in the expression analysis. Among these, 77.08% showed expression of at least one viral oncogene, with Conclusions: These findings reinforce the importance of further studies investigating HPV activity in breast tumors to better understand its biological and clinical impact.

Indexed as

breast cancer carcinogenesishuman papillomavirusPI3K/AKT/mTOR pathway

Identifiers

PMID42558973
PMCPMC13439120

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.