ArticleFrontiers in physiology2026
Association between free fatty acids and vascular calcification in CKD patients.
Article in Frontiers in physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Purpose: As an independent risk factor for cardiovascular events in patients with chronic kidney disease (CKD), the mechanism of vascular calcification (VC) remains unclear, and current treatments targeting known mechanisms have still failed to reduce its occurrence. The relationship between free fatty acids (FFAs) and vascular calcification has been confirmed in general population in recent years, but not in CKD patients. Therefore, we investigated the association between free fatty acids and vascular calcification in CKD patients. Methods: A total of 103 patients diagnosed with CKD stage 3-4 were included in this cross-sectional study. The severity of VC in this population was evaluated by abdominal aortic calcification score (AACS). Univariate binary logistic regression analysis was used for univariate analysis. Parameters with Results: The serum FFAs levels were significantly increased in the group with AAC scores ≥ 5 group [0.67 (0.65, 1.13) mmol/L vs. 0.62 (0.39, 0.65) mmol/L, Conclusion: Elevated serum FFAs are associated with vascular calcification severity in patients with CKD stage 3-4.
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