ArticleFrontiers in medicine2026
Art an 3 as a candidate recombinant antigen for Artemisia pollen immunotherapy: comparative efficacy and mechanistic insights.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Artemisia pollen is a major cause of seasonal respiratory allergy, yet allergen-specific immunotherapy (AIT) still relies mainly on crude extracts. Art an 3 is a major Objective: To compare recombinant Art an 3 (rArt an 3)-based versus extract-based subcutaneous immunotherapy (SCIT) in an Methods: Female BALB/c mice were sensitized and intranasally challenged with Results: Both SCIT regimens reduced peribronchial inflammation, goblet-cell mucus, and methacholine-induced AHR versus positive controls; histologic improvement tended to be greater with Extracts-SCIT, whereas AHR improvement was comparable. Extracts-SCIT more clearly decreased BALF eosinophils and IL-5/IL-17A. rArt an 3-SCIT preferentially increased IL-10 and IFN- Conclusion: rArt an 3-SCIT showed overall protection comparable to Extracts-SCIT, with a regulatory/Th1-associated profile characterized by increased Treg/Th1 responses and pollen-specific sIgG1, supporting rArt an 3 as a molecularly defined AIT candidate for Artemisia pollen allergy.
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