Exploring the Binding Specificity of Siglec-Derived Peptides to Human Primary Amine Oxidase Using an Integrative Approach to Ligand Epitope Mapping.

Marion Alix, Mikael Londen, Gabriela Guédez, Ana Sofia Grosso, Filipa Marcelo, Eurico Cabrita, Tiina Annamaria Salminen

Abstract read

In one paragraph

Article in Computational and structural biotechnology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marion AlixStructural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, Tykistökatu 6A, 20520 Turku, Finland.ORCID https://orcid.org/0000-0002-3751-0077

Mikael LondenStructural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, Tykistökatu 6A, 20520 Turku, Finland.ORCID https://orcid.org/0000-0001-6017-1395

Gabriela GuédezStructural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, Tykistökatu 6A, 20520 Turku, Finland.ORCID https://orcid.org/0000-0002-3711-8470

Ana Sofia GrossoUCIBIO-Applied Molecular Biosciences Unit, Department of Chemistry, NOVA School of Science and Technology, 2829-516 Caparica, Portugal.ORCID https://orcid.org/0000-0001-5324-4998

Filipa MarceloUCIBIO-Applied Molecular Biosciences Unit, Department of Chemistry, NOVA School of Science and Technology, 2829-516 Caparica, Portugal.ORCID https://orcid.org/0000-0001-5049-8511

Eurico CabritaUCIBIO-Applied Molecular Biosciences Unit, Department of Chemistry, NOVA School of Science and Technology, 2829-516 Caparica, Portugal.ORCID https://orcid.org/0000-0002-0720-2751

Tiina Annamaria SalminenStructural Bioinformatics Laboratory, Biochemistry, Faculty of Science and Engineering, Åbo Akademi University, Tykistökatu 6A, 20520 Turku, Finland.ORCID https://orcid.org/0000-0002-4135-8020

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human primary amine oxidase (AOC3) is a membrane-anchored protein expressed on the luminal surface of the vascular endothelium at sites of inflammation. It binds via protein-protein interactions to the CE-loops of the C2

Identifiers

PMID42558753

DOI10.34133/csbj.0195

PMCPMC13438033

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.