ReviewFrontiers in immunology2026
Mapping immune responses to TAK-003 dengue vaccine: immunogenicity across the clinical development program.
Review in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite deployment of vector control and prevention strategies, dengue remains a substantial threat to public health. Development of an effective vaccine against dengue has been challenging due to the need for simultaneous immunity against all four dengue virus serotypes, durable protection regardless of prior dengue exposure, and the complex epidemiological patterns of serotype co-circulation. As part of the clinical development of TAK-003, a live attenuated tetravalent dengue vaccine based on a DENV-2 backbone, extensive profiling of post-vaccination immune responses has been performed in participants who were dengue-naive or previously-exposed at baseline across dengue-endemic and non-endemic regions. In this review, we summarise the magnitude, quality, and functionality of humoral and cellular immune responses following the first and second doses of TAK-003 across age, region, and DENV serotype. We also outline long-term persistence and durability, ongoing investigations into correlates of protection, age-stratified responses, and evidence on co-administration with other vaccines.
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