Evidence map›Paper›PMID 42558614›Full record

ArticleFrontiers in reproductive health2026

Evaluating infant feeding practice guidelines for individuals with HIV: a pilot study using qualitative findings with healthcare workers and normalization process theory.

Julia D López, Elaine Schmidt, Kneeshe Parkinson, Virginia McKay, Sydney M Thayer, Amanda Zofkie

Abstract read
In one paragraph

Article in Frontiers in reproductive health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Julia D LópezDivision of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Elaine SchmidtBrown School, Washington University in St. Louis, St. Louis, MO, United States.
Kneeshe ParkinsonMidwest D-CFAR, Washington University School of Medicine, St. Louis, MO, United States.
Virginia McKayBursky School of Public Health, Washington University in St. Louis, St. Louis, MO, United States.
Sydney M Thayer *Department of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine, Washington University School of Medicine, St. Louis, MO, United States.
Amanda Zofkie *Department of Obstetrics & Gynecology, Division of Maternal-Fetal Medicine, Washington University School of Medicine, St. Louis, MO, United States.

Funding

Scientific Working GroupP30AI176532 · NIAID · WASHINGTON UNIVERSITY · PI Michael Joseph Durkin · 2024 to 2026
$5.6M
NIAID NIH HHS P30 AI176532
6 · The paper itself

Abstract

Introduction: In 2023, the WHO and CDC updated HIV infant feeding guidelines, emphasizing the role of antiretroviral therapy (ART) in reducing breastfeeding/chestfeeding transmission risk among birthing people living with HIV (BPLWH). Despite this update, clinical integration remains inconsistent, shaped by provider knowledge, bias, patient engagement, and systemic barriers. Materials & methods: Between August 2025 and January 2026, we conducted 10 semi-structured, in-depth interviews with healthcare workers (HCWs) to assess their understanding of and engagement with updated HIV breastfeeding/chestfeeding guidelines. The Normalization Process Theory (NPT) informed the development of the interview guide and the thematic analysis. Transcripts were double-coded in Dedoose and thematic analysis was conducted deductively. Results: Healthcare workers generally accepted the guidelines as evidence-based, but their implementation varied across the four NPT constructs. While the guidelines were seen as logically coherent, OB-GYNs highlighted reproductive autonomy, whereas infectious disease and pediatric providers prioritized infant HIV susceptibility. Uncertainty about viral load thresholds led to variability among providers. Ethical motivation strongly supported implementation, but inconsistent training and low patient volumes reduced confidence. Institutional leaders and interdisciplinary workflows were identified as vital facilitators. Major obstacles included fragmented OB-GYN-to-pediatrics handoffs, services located in different areas, and structural patient burdens such as monitoring requirements and insurance issues, which the guidelines did not specifically address. Discussion: Systematically identifying how new breastfeeding/chestfeeding practices become embedded in healthcare among HCWs, and assessing where knowledge gaps, misunderstandings, and engagement barriers exist regarding the guidelines, will inform the development of a decision-making guide to enhance implementation of HIV breastfeeding/chestfeeding guidelines for pregnant people.

Indexed as

breastfeeding/ChestfeedingHIVmaternal and fetal medicinenormalization process theoryobstetrics and gynecologypediatricspilot studypregnant people

Identifiers

PMID42558614
PMCPMC13437786

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.