ArticleFrontiers in molecular neuroscience2026
Article in Frontiers in molecular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
2 authors.
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Abstract
Introduction: Chronic cold stress acts as an influential environmental stressor that disrupts neuro-behavioral functions, which include anxiety responses, cognitive performance, mood regulation, and stress susceptibility. In spite of the growing recognition of cold-induced neuropathology, effective therapeutic strategies remain limited. Methods: Structured phytochemical characterization of saffron extract was performed using UV-visible spectroscopy, Fourier transform infrared spectroscopy, gas chromatography-mass spectrometry, and high-performance liquid chromatography. The antioxidant profile of the extract using 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity was analyzed, along with the assessment of total phenolic content, total flavonoid content and moisture content. Chronic cold exposure was induced at 4°C for 30 min/day over a period of 4 weeks. Neurobehavioral parameters of general exploration, anxiety, and memory were evaluated using established behavioral assessment paradigms of open field, elevated plus maze, Y-maze, and novel object recognition, respectively. Results: Phytochemical characterization of saffron extract confirmed the presence of major bioactive constituents, including crocin and safranal. Additionally, a high phenolic and flavonoid content was supported by a robust antioxidant activity Conclusion: Saffron extract enhances neurobehavioral functions, significantly ameliorating cold stress-induced cognitive deficits and anxiety-like behavior. While these findings support its neuroprotective potential in stress-related neuropsychiatric disorders, the underlying mechanisms require further investigation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.