Factors and outcomes of pediatric sepsis under an antimicrobial stewardship program in a tertiary care teaching hospital in Thailand: a retrospective cohort study.

Objective: To investigate the factors associated with mortality and the outcomes of an antimicrobial stewardship program (ASP) in pediatric patients with sepsis. Design: Retrospective cohort study. Setting: A tertiary care teaching hospital in Thailand. Patients: Pediatric patients with sepsis. Methods: This study reviewed electronic medical records of pediatric patients. A computer-generated random sequence was used to select 240 patients who met the inclusion criteria for the analysis. Results: Between January 1, 2021, and December 31, 2024, a total of 1,777 patients were enrolled in the ASP. Of 240 eligible patients, males accounted for 56.7% of the cohort, with a median age of 1.0 year (interquartile range 0-6). Positive blood cultures were identified in 72 patients (30.0%). ASP interventions identified antibiotic-related problems in 93 patients (38.8%), with primary physicians adhering to ASP recommendations in 55 cases (59.1%). Septic shock was the only factor significantly associated with 30-day mortality (adjusted odds ratio 4.064; 95% confident interval: CI 1.265-13.061; Conclusions: Septic shock was the only factor associated with 30-day mortality. ASP help detected antibiotic-related problems and reduced meropenem and vancomycin consumption in pediatric patients with sepsis.