Evidence map›Paper›PMID 42558510›Full record

ArticleFrontiers in immunology2026

Recombinant

Zhile Xiong, Xiuju Liu, Xiaoying Deng, Chao Zhang, Kaiyue Yang, Zhimin Zhao, Tongyan Ding, Shuyan Liu, Zhenwen Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhile XiongClinical Laboratory, Key Laboratory of Bacterial Resistance and Prevention, Medical Research Institute of Maternal and Child, Affiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College (Longgang District Maternity & Child Healthcare Hospital of Shenzhen City), Shenzhen, China.
Xiuju LiuClinical Laboratory, Key Laboratory of Bacterial Resistance and Prevention, Medical Research Institute of Maternal and Child, Affiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College (Longgang District Maternity & Child Healthcare Hospital of Shenzhen City), Shenzhen, China.
Xiaoying DengDepartment of Gastrointestinal Surgery, Department of General Surgery, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Chao ZhangClinical Laboratory, Key Laboratory of Bacterial Resistance and Prevention, Medical Research Institute of Maternal and Child, Affiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College (Longgang District Maternity & Child Healthcare Hospital of Shenzhen City), Shenzhen, China.
Kaiyue YangClinical Laboratory, Key Laboratory of Bacterial Resistance and Prevention, Medical Research Institute of Maternal and Child, Affiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College (Longgang District Maternity & Child Healthcare Hospital of Shenzhen City), Shenzhen, China.
Zhimin ZhaoClinical Laboratory, Key Laboratory of Bacterial Resistance and Prevention, Medical Research Institute of Maternal and Child, Affiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College (Longgang District Maternity & Child Healthcare Hospital of Shenzhen City), Shenzhen, China.
Tongyan DingClinical Laboratory, Key Laboratory of Bacterial Resistance and Prevention, Medical Research Institute of Maternal and Child, Affiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College (Longgang District Maternity & Child Healthcare Hospital of Shenzhen City), Shenzhen, China.
Shuyan LiuClinical Laboratory, Key Laboratory of Bacterial Resistance and Prevention, Medical Research Institute of Maternal and Child, Affiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College (Longgang District Maternity & Child Healthcare Hospital of Shenzhen City), Shenzhen, China.
Zhenwen ZhouClinical Laboratory, Key Laboratory of Bacterial Resistance and Prevention, Medical Research Institute of Maternal and Child, Affiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College (Longgang District Maternity & Child Healthcare Hospital of Shenzhen City), Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Although oral immunotherapy has shown clinical efficacy in treating food allergies, its broader implementation is constrained by the occurrence of adverse effects. Consequently, inducing allergen-specific immune tolerance during early life can be a preventive strategy to reduce the development of food allergy. Objective: Here, we developed a novel fusion protein cholera toxin B (CTB)-ovalbumin (OVA) expressed on Method: Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) and Western blot were used to confirm that CTB-OVA was expressed on Results: Recombinant CTB-OVA was successfully expressed on the surface of Conclusion: These findings suggest that

Indexed as

Bacillus subtilisCholera ToxinFood HypersensitivityGastrointestinal MicrobiomeOvalbuminSpores, BacterialT-Lymphocytes, RegulatoryAllergensAnimalsCytokinesDisease Models, AnimalFemaleImmune ToleranceImmunoglobulin EMiceMice, Inbred BALB CAllergensCholera ToxinCytokinesImmunoglobulin EOvalbuminBacillus subtilisfecal microbiota transplantmicrobiomeoral toleranceOVA-food allergyTreg

Identifiers

PMID42558510
PMCPMC13437438

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.