Evidence map›Paper›PMID 42558378›Full record

ArticleFrontiers in microbiology2026

Extracellular vesicles from pasteurized

Ling Zou, Zhilong Jia, Yutong Shu, Xiang You, Jingjing Ma, Yu Wang, Jinhan He, Yining Xu

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ling ZouDepartment of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital, Sichuan University, Chengdu, China.
Zhilong JiaKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, West China School of Pharmacy, Sichuan University, Chengdu, China.
Yutong ShuKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, West China School of Pharmacy, Sichuan University, Chengdu, China.
Xiang YouKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, West China School of Pharmacy, Sichuan University, Chengdu, China.
Jingjing MaKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, West China School of Pharmacy, Sichuan University, Chengdu, China.
Yu WangDepartment of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital, Sichuan University, Chengdu, China.
Jinhan HeDepartment of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital, Sichuan University, Chengdu, China.
Yining XuDepartment of Pharmacy, Institute of Metabolic Diseases and Pharmacotherapy, West China Hospital, Sichuan University, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: A dextran sulfate sodium (DSS)-induced mouse model of colitis was used to evaluate the therapeutic effects of PAEVs and AEVs. Disease severity, body weight loss, colonic histopathology, inflammatory cytokine expression, intestinal barrier integrity, inflammatory signaling pathways, and gut microbiota composition were assessed. Results: PAEVs markedly attenuated DSS-induced colitis, as evidenced by reduced weight loss, improved colonic histology, decreased levels of TNF- Discussion: These findings indicate that PAEVs effectively alleviate experimental IBD by enhancing tight junction proteins, suppressing some inflammatory cytokines, and modulating gut microbiota composition. Compared with AEVs, PAEVs exhibit broader protective effects, suggesting that extracellular vesicles derived from pasteurized

Indexed as

Akkermansia muciniphilaextracellular vesiclesgut microbiotainflammatory bowel diseasepasteurizedSTING/IκB/NF-κB signaling axis

Identifiers

PMID42558378
PMCPMC13437525

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.