ArticleFrontiers in cellular neuroscience2026
Voluntary running reduces loss of PTEN-deficient Purkinje cells, modulates their metabolic signaling, and improves motor deficits in mice.
Article in Frontiers in cellular neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Dysregulation of the PTEN-mTORC1 signaling pathway disrupts cellular metabolism and contributes to neurodevelopmental disorders, including autism spectrum disorder (ASD). In cerebellar Purkinje cells (PCs), PTEN deficiency leads to hyperactivation of mTORC1, impaired energy homeostasis, and progressive neuronal degeneration. Given that physical exercise is a potent modulator of metabolic signaling, we investigated whether voluntary running could restore metabolic balance and ameliorate cellular and behavioral deficits in a mouse model of PC-specific PTEN deficiency. Using
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