ArticleFrontiers in cellular and infection microbiology2026
Mannan immunoassay for diagnosis of invasive mucormycosis: assay development, preclinical testing and evaluation in an animal model.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Early diagnosis of mucormycosis would be greatly facilitated by identification of a non-invasive biomarker for infection. This study evaluated whether detection of Mucorales mannan in serum or bronchoalveolar lavage fluid (BALF) can serve as such a biomarker. To date, mannan has been found in body fluids of invasive disease caused by many ascomycetous fungal pathogens, but its presence has not been evaluated for disease-producing members of the Mucorales. We utilized a monoclonal antibody (mAb) that is reactive with Mucorales mannan to construct a lateral flow immunoassay (LFA) containing labeled europium nanoparticles as the detector reagent. Analytical inclusivity studies found that the LFA detected mannans from four of the five disease-producing Mucorales fungi. No cross-reactivity was observed with purified mannans from other major causes of invasive fungal infection, i.e.
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