ArticleJournal of advanced periodontology & implant dentistry2026
Association of oxidative stress-related gst gene polymorphisms with periodontitis susceptibility: A systematic review and meta-analysis.
Article in Journal of advanced periodontology & implant dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Periodontitis is a prevalent inflammatory disease influenced by both genetic and environmental factors. Among genetic determinants, polymorphisms in oxidative stress-related g e n e s - p a r t i c u l a r l y Methods: Following PRISMA 2020 guidelines, a comprehensive literature search was conducted in four databases (PubMed, Scopus, Web of Science, and Google Scholar) from inception to October 2025 for eligible case‒control studies. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Heterogeneity was assessed using I Results: Seven studies with 1,525 participants were included. The GSTM1-null polymorphism was significantly associated with periodontitis (OR=2.94, 95% CI: 1.13-7.63, I2=93.5%) in subgroup analyses, particularly among Asians, in larger studies, and among heavy smokers. GSTT1-null polymorphism showed no significant effect (OR=0.64, 95% CI: 0.38-1.09, I Conclusion: This meta-analysis supports a potential role for the
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