ArticleJournal of advanced periodontology & implant dentistry2026
Salivary antibody responses to
Article in Journal of advanced periodontology & implant dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Periodontitis is a chronic inflammatory disease that leads to the destruction of tooth-supporting tissues and remains a major cause of tooth loss worldwide. Its pathogenesis involves complex interactions between microbial pathogens and host immune responses, where salivary immunoglobulins serve as a first line of defense at mucosal surfaces. Identifying pathogen-specific salivary antibody responses that correlate with disease severity may provide noninvasive biomarkers for diagnosis and monitoring. The present work sought to explore how selected microbial pathogens and salivary antibody responses are connected with the severity of periodontitis and clinical periodontal status. Methods: A cross-sectional approach was applied. Saliva was obtained from 39 participants, including 31 patients diagnosed with periodontitis and 8 individuals with healthy periodontal tissues. Western blotting and enzyme-linked immunoassays were used to detect both microorganisms and immunoglobulins. Results: Patients classified as Stage IV periodontitis showed the highest occurrence of Conclusion: Salivary IgA and IgG responses to
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