Evidence map›Paper›PMID 42557932›Full record

Observational studyAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Lecanemab use in Chinese patients with Alzheimer's disease: a 12-month multicenter real-world study.

Hao Wu, Qin Chen, Min Fang, Huidong Tang, Huayan Liu, Jun Liu, Jiewen Zhang, Lijun Chi, Shuai Liu, Jiawei Xin and 26 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Hao WuDepartment of Neurology, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Huanhu Hospital Affiliated to Tianjin Medical University, Tianjin, China.
Qin ChenDepartment of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Min FangDepartment of Neurology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Huidong TangDepartment of Geriatrics, Medical Center on Aging, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Huayan LiuDepartment of Neurology, First Hospital of China Medical University, Shenyang, Liaoning, China.
Jun LiuDepartment of Neurology, Institute of Neuroscience, Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, China.
Jiewen ZhangDepartment of Neurology, Zhengzhou University People's Hospital, Henan University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
Lijun ChiDepartment of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Shuai LiuDepartment of Neurology, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Huanhu Hospital Affiliated to Tianjin Medical University, Tianjin, China.
Jiawei XinDepartment of Neurology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Molecular Neurology and Institute of Neuroscience, Fujian Medical University, Fuzhou, Fujian, China.
Lumin LengDepartment of Neurology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Pan WangDepartment of Neurology, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Huanhu Hospital Affiliated to Tianjin Medical University, Tianjin, China.
Song ChiDepartment of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Yi LiDepartment of Neurology, Qilu Hospital, Shandong University, Jinan, Shandong, China.
Jianwen ChenDepartment of Neurology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China.
Ligong ZhangDepartment of Neurology, Shengli Oilfield Central Hospital, Dongying, Shandong, China.
Jinhong ZhangDepartment of Neurology, Cangzhou People's Hospital, Cangzhou, Hebei, China.
Qiang MaDepartment of Neurology, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, China.
Xuezhen WangDepartment of Neurology, Affiliated Hospital of Binzhou Medical University, Binzhou, Shandong, China.
Xinling MengDepartment of Brain Disease, Affiliated Traditional Chinese Medicine Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China.
Jianfei NaoDepartment of Neurology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Xiangqing LiDepartment of Neurology, Zibo Central Hospital, Zibo, Shandong, China.
Yan LvDepartment of Neurology, Hainan General Hospital, Haikou, Hainan, China.
Yanhong JiaDepartment of Neurology, Baotou Central Hospital, Baotou, Inner Mongolia, China.
Qing ZhaoDepartment of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
Chunyan LiuDepartment of Neurology, Aviation General Hospital, Beijing, China.
Jinghuan GanDepartment of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Jing ZhuDepartment of Neurology, Linfen Central Hospital, Linfen, Shanxi, China.
Yehua SongDepartment of Neurology, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, Fujian, China.
Huaian LiDepartment of Geriatrics, Qinhuangdao Hospital of Dongfang Hospital, Beijing University of Chinese Medicine, Qinhuangdao Hospital of Traditional Chinese Medicine, Qinhuangdao, Hebei, China.
Min FeiDepartment of Neurology, Yuncheng Central Hospital, Yuncheng, Shanxi, China.
Xia GuoDepartment of Neurology, The First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia, China.
Jingwen LiuDepartment of Neurology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
Guoping PengDepartment of Neurology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Xiaochun ChenDepartment of Neurology, Fujian Medical University Union Hospital, Fujian Key Laboratory of Molecular Neurology and Institute of Neuroscience, Fujian Medical University, Fuzhou, Fujian, China.
Yong JiDepartment of Neurology, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Huanhu Hospital Affiliated to Tianjin Medical University, Tianjin, China.

Funding

Tianjin Key Medical Discipline Construction Project TJYXZDXK-3-014B
6 · The paper itself

Abstract

introductionWe evaluated lecanemab's safety and cognitive outcomes in Chinese patients with Alzheimer's disease (AD) and the utility of blood-based biomarkers (BBMs) for treatment guidance.

methodsA multicenter, real-world cohort enrolled 1042 patients receiving lecanemab, with 453, 359, 97 patients followed up at 3, 6, 12 months, respectively. Safety outcomes included amyloid-related imaging abnormalities (ARIA) and infusion-related reactions (IRRs), and the main clinical outcome was Clinical Dementia Rating Scale-Sum of Boxes (CDR-SB) score change.

resultsOf 1,042 patients, ARIA occurred in 7.87%, and IRRs in 16.12%. Discontinuation was 16.51%, mainly due to financial burden. CDR-SB did not change at 12 months overall or in any subgroup. High-accuracy BBMs were the sole AD biomarker assay in 5.28%, with comparable outcomes. DISCUSSION: Lecanemab exhibited favorable 12-month safety, with no clear evidence of cognitive decline, and BBMs hold potential for treatment guidance. Further studies using a control group are now warranted.

Indexed as

Alzheimer DiseaseAntibodies, Monoclonal, HumanizedAgedAged, 80 and overAmyloid beta-PeptidesBiomarkersChinaFemaleHumansMaleTreatment OutcomeAmyloid beta-PeptidesAntibodies, Monoclonal, HumanizedBiomarkerslecanemabAlzheimer's diseaseamyloid‐related imaging abnormalitiesblood‐based biomarkersefficacylecanemabreal‐world study

Identifiers

PMID42557932
PMCPMC13444352

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.