Evidence map›Paper›PMID 42557820›Full record

ArticleDiabetes/metabolism research and reviews2026

Serum Bone-, Muscle- and Fat- Derived Factors Sclerostin, Irisin and Leptin Show Different Correlations With Body Composition and Bone Mineral Density in Chinese Men With Obesity: A Cross-Sectional Study.

Xiang Chen, Sumin Shen, Mingxi Zou, Zhenlin Zhang, Nanwei Tong, Juan Li

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Article in Diabetes/metabolism research and reviews, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Xiang ChenLaboratory of Endocrinology and Metabolism, Division of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Sumin ShenDepartment of Science and Technology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Mingxi ZouDepartment of Science and Technology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Zhenlin ZhangDivision of Endocrinology and Metabolism, Laboratory of Diabetes and Metabolism Research, West China Hospital, Sichuan University, Chengdu, Sichuan, China.ORCID https://orcid.org/0009-0003-9677-9580
Nanwei TongDivision of Endocrinology and Metabolism, Laboratory of Diabetes and Metabolism Research, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Juan LiDepartment of Diagnostics, West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.

Funding

Sichuan Provincial Department of Science and Technology Project 2024YFFK0291
6 · The paper itself

Abstract

aimsThis study aimed to explore the interactions among sclerostin, irisin and leptin, as well as their associations with body composition and bone metabolism in Chinese men with obesity. MATERIALS AND

methodsThis study included 26 men with normal weight and 78 men with obesity. Body composition was measured using dual-emission X-ray absorptiometry. Subcutaneous fat, visceral fat and fat content in the liver and pancreas were determined by magnetic resonance. Serum sclerostin, irisin and leptin were detected using the Elisa assay.

resultsCompared with men with normal weight, serum sclerostin, irisin and leptin levels as well as whole-body and spinal bone mineral density were increased, whereas pelvic bone mineral density was not different in men with obesity. Partial analysis showed that in men with obesity, serum sclerostin was positively correlated with bone mineral density but not with body composition; serum irisin was positively correlated with fat mass percent, negatively correlated with muscle mass percent, but not with bone mineral density; serum leptin was positively correlated with fat mass, while negatively associated with muscle mass and bone mineral density. Furthermore, body weight showed beneficial effects on whole-body and spinal bone, whereas central fat distribution exerted adverse effects on pelvic bone. Stepwise linear regression revealed that serum sclerostin and whole-body muscle mass were independent predictors of bone mineral density in the over-all cohort.

conclusionsSerum sclerostin, irisin and leptin show distinct correlations with body composition and bone mineral density in men with obesity, which may partly reflect the complex effects of obesity on bone metabolism.

Indexed as

Body CompositionBone DensityBone Morphogenetic ProteinsFibronectinsLeptinObesityAdaptor Proteins, Signal TransducingAdultBiomarkersBone and BonesChinaCross-Sectional StudiesGenetic MarkersHumansMaleMiddle AgedAdaptor Proteins, Signal TransducingBiomarkersBone Morphogenetic ProteinsFibronectinsFNDC5 protein, humanGenetic MarkersLeptinSOST protein, humanbone metabolismirisinleptinobesitysclerostin

Identifiers

PMID42557820
PMCPMC13443498

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