Evidence map›Paper›PMID 42557794›Full record

ArticleBioMed research international2026

Protective Effects of Donkey Milk-Derived Exosomes Against UVB-Induced Skin Photoaging via Regulation of DNA Damage and Aging-Related Pathways.

Jie Yu, Jinni Sun, Jie Cheng, Guangyuan Liu, Pengxiang Niu, Qian Liu, Zhaoting Wang, Ying Huo, Hang Tie, Cong Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jie YuDong-E E-Jiao Co. Ltd, Liaocheng, Shandong, China.
Jinni SunDong-E E-Jiao Co. Ltd, Liaocheng, Shandong, China.
Jie ChengDong-E E-Jiao Co. Ltd, Liaocheng, Shandong, China.
Guangyuan LiuDong-E E-Jiao Co. Ltd, Liaocheng, Shandong, China.
Pengxiang NiuTianjin Key Laboratory of Animal and Plant Resistance, College of Life Sciences, Tianjin Normal University, Tianjin, China, tjnu.edu.cn.ORCID https://orcid.org/0009-0008-6367-1326
Qian LiuTianjin Key Laboratory of Animal and Plant Resistance, College of Life Sciences, Tianjin Normal University, Tianjin, China, tjnu.edu.cn.ORCID https://orcid.org/0009-0007-5115-4797
Zhaoting WangTianjin Key Laboratory of Animal and Plant Resistance, College of Life Sciences, Tianjin Normal University, Tianjin, China, tjnu.edu.cn.ORCID https://orcid.org/0009-0008-2547-6618
Ying HuoTianjin Key Laboratory of Animal and Plant Resistance, College of Life Sciences, Tianjin Normal University, Tianjin, China, tjnu.edu.cn.ORCID https://orcid.org/0009-0008-4607-882X
Hang TieChinese Academy of Inspection and Quarantine Greater Bay Area, Zhongshan, Guangdong, China.ORCID https://orcid.org/0000-0001-9376-3493
Cong WangChinese Academy of Inspection and Quarantine Greater Bay Area, Zhongshan, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prolonged exposure to UVB radiation accelerates skin photoaging by inducing DNA damage, promoting collagen degradation, and triggering cellular senescence. There is a growing interest in identifying effective natural interventions to prevent or mitigate these adverse effects. This study investigated the protective role and underlying mechanisms of donkey milk-derived exosomes (DM-Exos) against UVB-induced skin aging using both in vitro skin cell models and in vivo mouse models. The results demonstrated that DM-Exos significantly reduced UVB-induced cellular senescence, as evidenced by decreased β-galactosidase activity and downregulation of senescence-associated genes. DM-Exos also attenuated intracellular ROS production and reduced DNA damage markers (γ-H2AX and 8-OHdG) both in vitro and in vivo. Transcriptomic analysis further revealed that DM-Exos mitigated UVB-induced alterations in pathways related to cellular senescence, DNA damage, cell proliferation, and response to UV radiation, which were corroborated by qPCR validation of key aging-related genes. These findings underscore the potential of DM-Exos as a promising natural agent for protecting against UVB-induced skin aging and maintaining overall skin health.

Indexed as

DNA DamageExosomesMilkSkin AgingUltraviolet RaysAnimalsCell ProliferationCellular SenescenceEquidaeHumansMiceReactive Oxygen SpeciesSkinReactive Oxygen SpeciesDNA damagedonkey milk-derived exosomesphotoagingsenescenceUVB

Identifiers

PMID42557794
PMCPMC13443119

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.