Evidence map›Paper›PMID 42557617›Full record

ArticleAdvanced healthcare materials2026

Solanum nigrum-Derived Carbon Dots Alleviate Tumor Hypoxia to Potentiate Photodynamic Therapy in Esophageal Squamous Cell Carcinoma.

Sheng-Nan Luo, Guang-Song Zheng, Jun Jin, Xin-Ling Wang, Wen-Yao Li, Na Xu, Wen-Jie Yang, Yu-Shi Chen, Jin-Tao Zhang, Qing Lou and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Sheng-Nan LuoState Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
Guang-Song ZhengHenan Key Laboratory of Diamond Materials and Devices, Key Laboratory of Material Physics, Ministry of Education, School of Physics, Zhengzhou University, Zhengzhou, China.
Jun JinState Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
Xin-Ling WangState Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.ORCID https://orcid.org/0009-0003-4738-0899
Wen-Yao LiState Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.ORCID https://orcid.org/0009-0007-5991-9125
Na XuState Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
Wen-Jie YangState Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
Yu-Shi ChenState Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
Jin-Tao ZhangState Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
Qing LouHenan Key Laboratory of Diamond Materials and Devices, Key Laboratory of Material Physics, Ministry of Education, School of Physics, Zhengzhou University, Zhengzhou, China.ORCID https://orcid.org/0000-0002-8852-8453
Zi-Sen ZhangState Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.
Li-Guo ZhangState Key Laboratory of Metabolic Dysregulation & Prevention and Treatment of Esophageal Cancer, Henan Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, China.ORCID https://orcid.org/0000-0002-3267-2253

Funding

Project of Basic Research Fund of Henan Institute of Medical and Pharmaceutical Sciences 2026BP0103Project of Basic Research Fund of Henan Institute of Medical and Pharmaceutical Sciences 2026BP0103-1Project of International Cultivation of Henan Advanced TalentsScientific and Technological Program of Henan Province 252102311195
6 · The paper itself

Abstract

Esophageal squamous cell carcinoma (ESCC) is highly prevalent and aggressive in China, with conventional therapies causing significant morbidity. Photodynamic therapy (PDT) kills tumor cells via photosensitizer-mediated reactive oxygen species (ROS), representing an effective tumor treatment. However, its efficacy is severely impaired by the hypoxic tumor microenvironment (TME). In this study, we synthesized multifunctional carbon dots (SN-CDs) from the traditional Chinese herb Solanum nigrum via hydrothermal method. SN-CDs (particle size: 1.9 ± 0.3 nm) are rich in hydroxyl and amino groups, with an oxygen generation rate of approximately 2.61 ppm/min in vitro. They can efficiently decompose endogenous hydrogen peroxide in the tumor microenvironment, thereby alleviating tumor hypoxia. Under 635 nm laser irradiation, they generate ROS (

Indexed as

CarbonCarbon Quantum DotsEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaPhotochemotherapySolanum nigrumTumor HypoxiaAnimalsApoptosisCell Line, TumorHumansMiceMice, Inbred BALB CMice, NudePhotosensitizing AgentsReactive Oxygen SpeciesCarbonPhotosensitizing AgentsReactive Oxygen Speciescarbon dotsdecomposition of hydrogen peroxideesophageal squamous cell carcinomahypoxic tumor microenvironmentphotodynamic therapyreactive oxygen speciesSolanum nigrum

Identifiers

PMID42557617
PMCPMC13542846

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.