Hematopoietic Growth Factors Induce More Extensive Transcriptomic Remodeling in Cerebral Monocytes/Macrophages than in Microglia During the Chronic Phase of Traumatic Brain Injury.

Sushil Gaire, Robert S Gardner, Michele Kyle, Xuecheng Qiu, William Miller, Lawrence S Chin, Li-Ru Zhao

Abstract read

In one paragraph

Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Sushil GaireDepartment of Neurosurgery, State University of New York Upstate Medical University, 750 E. Adams Street, Syracuse, NY, 13210, USA.

Robert S GardnerDepartment of Neurosurgery, State University of New York Upstate Medical University, 750 E. Adams Street, Syracuse, NY, 13210, USA.

Michele KyleDepartment of Neurosurgery, State University of New York Upstate Medical University, 750 E. Adams Street, Syracuse, NY, 13210, USA.

Xuecheng QiuDepartment of Neurosurgery, State University of New York Upstate Medical University, 750 E. Adams Street, Syracuse, NY, 13210, USA.

William MillerDepartment of Neurosurgery, State University of New York Upstate Medical University, 750 E. Adams Street, Syracuse, NY, 13210, USA.

Lawrence S ChinDepartment of Neurosurgery, State University of New York Upstate Medical University, 750 E. Adams Street, Syracuse, NY, 13210, USA.

Li-Ru ZhaoDepartment of Neurosurgery, State University of New York Upstate Medical University, 750 E. Adams Street, Syracuse, NY, 13210, USA. ZHAOL@upstate.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous studies show that combined treatment with stem cell factor (SCF) and granulocyte colony-stimulating factor (G-CSF) enhances brain repair and functional recovery during the chronic phase of severe traumatic brain injury (TBI), but the underlying mechanisms remain unclear. Here, we investigated whether SCF + G-CSF modulates brain immune cell states during chronic TBI. In a controlled cortical impact mouse model, SCF + G-CSF was administered subcutaneously for 5 consecutive days beginning 8 months post-injury. CD11b⁺ brain immune cells, including microglia and monocytes/macrophages (Mo/Mac), were isolated one day after the final injection and analyzed by single-cell RNA sequencing. Integrated analyses revealed more extensive transcriptomic changes in Mo/Mac than in microglia following SCF + G-CSF treatment. Flow cytometry confirmed a significant increase in the CD11b

Indexed as

Brain Injuries, TraumaticCerebral CortexGranulocyte Colony-Stimulating FactorMacrophagesMicrogliaMonocytesStem Cell FactorTranscriptomeAnimalsChronic DiseaseMaleMice, Inbred C57BLGranulocyte Colony-Stimulating FactorStem Cell FactorChronic traumatic brain injuryHematopoietic growth factorMacrophagesMicrogliaTranscriptomic analysisTraumatic brain injury

Identifiers

PMID42557490

DOI10.1007/s12035-026-06096-0

PMCPMC13442482

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.