Evidence map›Paper›PMID 42557486›Full record

ArticleSurgical endoscopy2026

Robotic versus laparoscopic liver resection for intrahepatic cholangiocarcinoma in elderly patients: a multicentre propensity-weighted analysis.

Antonella Delvecchio, Silvio Caringi, Rebecca Marino, Remo Alessandris, Simone Conci, Laura Alaimo, Enrico Gringeri, Clarissa De Nardi, Francesco Ardito, Simone Famularo and 26 more

Abstract read
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In one paragraph

Article in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Antonella DelvecchioUnit of Hepato-Biliary and Pancreatic Surgery, Ecclesiastical Entity Regional General Hospital "F. Miulli", Strada Prov. 127 Acquaviva - Santeramo Km. 4, 70021, Acquaviva Delle Fonti, Bari, Italy. a.delvecchio@miulli.it.ORCID http://orcid.org/0000-0002-7759-4340
Silvio CaringiUnit of Hepato-Biliary and Pancreatic Surgery, Ecclesiastical Entity Regional General Hospital "F. Miulli", Strada Prov. 127 Acquaviva - Santeramo Km. 4, 70021, Acquaviva Delle Fonti, Bari, Italy.
Rebecca MarinoHepatobiliary Surgery Division, IRCCS San Raffaele Scientific Institute, 20132, Milano, Milan, Italy.
Remo AlessandrisHepatobiliary Surgery Division, IRCCS San Raffaele Scientific Institute, 20132, Milano, Milan, Italy.
Simone ConciDivision of General and Hepatobiliary Surgery, University Hospital G.B. Rossi, 37134, Verona, Italy.
Laura AlaimoDivision of General and Hepatobiliary Surgery, University Hospital G.B. Rossi, 37134, Verona, Italy.
Enrico GringeriHepato-Biliary-Pancreatic Surgery and Liver Transplantation Unit, Padua University Hospital, 35128, Padua, Italy.
Clarissa De NardiHepato-Biliary-Pancreatic Surgery and Liver Transplantation Unit, Padua University Hospital, 35128, Padua, Italy.
Francesco ArditoHepatobiliary Surgery Division, Foundation University Hospital "Agostino Gemelli" IRCCS, 00168, Rome, Italy.
Simone FamularoHepatobiliary Surgery Division, Foundation University Hospital "Agostino Gemelli" IRCCS, 00168, Rome, Italy.
Leonardo CentonzeDepartment of General Surgery and Transplantation, ASST Grande Ospedale Metropolitano Niguarda, 20162, Milano, Milan, Italy.
Vincenzo BuscemiDepartment of General Surgery and Transplantation, ASST Grande Ospedale Metropolitano Niguarda, 20162, Milano, Milan, Italy.
Federico MocchegianiHepato-Pancreato-Biliary and Transplant Surgery, Department of Experimental and Clinical Medicine, Polytechnic University of Marche, 60126, Ancona, Italy.
Andrea Benedetti CacciaguerraHepato-Pancreato-Biliary and Transplant Surgery, Department of Experimental and Clinical Medicine, Polytechnic University of Marche, 60126, Ancona, Italy.
Andrea BelliUnit of Hepato-Biliary and Pancreatic Surgery, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, 80131, Naples, Italy.
Maria Novella RingressiHepato-Biliary and Pancreatic Surgery, Careggi University Hospital, 50134, Florence, Italy.
Matteo SerenariHepato-Biliary Surgery and Transplant Unit, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, 40138, Bologna, Italy.
Fabio GiannoneHepato-Pancreato-Biliary, Oncologic and Robotic Unit, Azienda Ospedaliero-Universitaria SS, Antonio e Biagio E Cesare Arrigo, 15121, Alessandria, Italy.
Annarita LibiaDepartment of General Surgery and sub-specialty, Asl Lecce, Piazza Filippo Muratore, 73100, Lecce, Italy.
Declan McDonnellHepato-Pancreato-Biliary (HPB) Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK.
Fabrizio Di FrancescoDepartment Abdominal Center IRCCS-ISMETT, 90127, Palermo, Italy.
Michele TedeschiUnit of Hepato-Biliary and Pancreatic Surgery, Ecclesiastical Entity Regional General Hospital "F. Miulli", Strada Prov. 127 Acquaviva - Santeramo Km. 4, 70021, Acquaviva Delle Fonti, Bari, Italy.
Salvatore GruttadauriaDepartment Abdominal Center IRCCS-ISMETT, 90127, Palermo, Italy.
Marcello Giuseppe SpampinatoDepartment of General Surgery and sub-specialty, Asl Lecce, Piazza Filippo Muratore, 73100, Lecce, Italy.
Fabrizio PanaroHepato-Pancreato-Biliary, Oncologic and Robotic Unit, Azienda Ospedaliero-Universitaria SS, Antonio e Biagio E Cesare Arrigo, 15121, Alessandria, Italy.
Matteo CesconHepato-Biliary Surgery and Transplant Unit, IRCCS Azienda Ospedaliero-Universitaria Di Bologna, 40138, Bologna, Italy.
Gian Luca GraziHepato-Biliary and Pancreatic Surgery, Careggi University Hospital, 50134, Florence, Italy.
Francesco IzzoUnit of Hepato-Biliary and Pancreatic Surgery, Istituto Nazionale Tumori IRCCS Fondazione G. Pascale, 80131, Naples, Italy.
Marco VivarelliHepato-Pancreato-Biliary and Transplant Surgery, Department of Experimental and Clinical Medicine, Polytechnic University of Marche, 60126, Ancona, Italy.
Stefano Di SandroDepartment of General Surgery and Transplantation, ASST Grande Ospedale Metropolitano Niguarda, 20162, Milano, Milan, Italy.
Luciano de CarlisHPB Surgery Unit, Pederzoli Hospital, Peschiera del Garda (VR), 37019, Verona, Italy.
Felice GiulianteHepatobiliary Surgery Division, Foundation University Hospital "Agostino Gemelli" IRCCS, 00168, Rome, Italy.
Umberto CilloHepato-Biliary-Pancreatic Surgery and Liver Transplantation Unit, Padua University Hospital, 35128, Padua, Italy.
Andrea RuzzenenteDivision of General and Hepatobiliary Surgery, University Hospital G.B. Rossi, 37134, Verona, Italy.
Francesca RattiHepatobiliary Surgery Division, IRCCS San Raffaele Scientific Institute, 20132, Milano, Milan, Italy.
Riccardo MemeoUnit of Hepato-Biliary and Pancreatic Surgery, Ecclesiastical Entity Regional General Hospital "F. Miulli", Strada Prov. 127 Acquaviva - Santeramo Km. 4, 70021, Acquaviva Delle Fonti, Bari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEvidence comparing robotic and laparoscopic minimally invasive liver surgery (MILS) for intrahepatic cholangiocarcinoma (iCCA) in elderly patients remains limited. This study compared perioperative and oncological outcomes between the two approaches and identified factors associated with postoperative complications.

methodsA multicentre retrospective study was conducted across 13 high-volume hepatobiliary centres including consecutive patients aged ≥ 70 years undergoing MILS for iCCA. Propensity score-based inverse probability of treatment weighting (IPTW) was applied. Perioperative, pathological, and survival outcomes were analyzed.

resultsA total of 272 patients were included (194 laparoscopic, 78 robotic). After IPTW adjustment, robotic surgery showed a trend toward lower overall postoperative complication rates (16.2 vs 30.9%; p = 0.050), significantly lower rates of severe complications (6.6 vs 11.0%; p = 0.027), shorter hospital stay (6.5 vs 8.7 days; p < 0.001), and lower conversion rates (3.8 vs 15.4%; p < 0.001). At multivariable analysis, robotic surgery remained independently associated with reduced postoperative morbidity (OR 0.47, 95% CI 0.30-0.73; p < 0.001), whereas higher IWATE difficulty score and conversion to open surgery were independently associated with postoperative complications. The robotic approach was also associated with a higher lymph node yield after IPTW adjustment (8.3 ± 6.1 vs 5.4 ± 4.6; p = 0.005), while disease-free and overall survival were comparable between groups during the available follow-up. Although 90-day mortality was higher in the robotic group, only five deaths occurred overall.

conclusionsRobotic liver resection in elderly patients with iCCA was associated with improved short-term perioperative outcomes and lower conversion rates without evidence of inferior oncological outcomes. The higher 90-day mortality observed in the robotic group should be interpreted cautiously given the limited number of events. Operative complexity and conversion to open surgery were major determinants of postoperative morbidity.

Indexed as

Elderly patientsIntrahepatic cholangiocarcinomaLaparoscopic liver resectionMinimally invasive liver surgeryPropensity score weightingRobotic liver surgery

Identifiers

PMID42557486

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