Evidence map›Paper›PMID 42557444›Full record

ArticleNature neuroscience2026

Hippocampal CA3 connectomics reveals a gradient of mossy fiber inputs and selective feedforward inhibition onto pyramidal cells.

Zhihao Zheng, Changjoo Park, Eric W Hammerschmith, Ran Lu, Szi-Chieh Yu, Marissa Sorek, Ben Silverman, Chris S Jordan, Amy R Sterling, William M Silversmith and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Zhihao Zheng *Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA. zhihaoz@princeton.edu.ORCID http://orcid.org/0000-0001-9406-9073
Changjoo Park *Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0009-0008-1847-2387
Eric W Hammerschmith *Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Ran LuPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0000-0002-2077-8165
Szi-Chieh YuPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0009-0001-9684-0156
Marissa SorekPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID http://orcid.org/0009-0008-7636-0746
Ben SilvermanPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Chris S JordanPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Amy R SterlingPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
William M SilversmithPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Philipp SchlegelNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID http://orcid.org/0000-0002-5633-1314
Gregory S X E JefferisNeurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID http://orcid.org/0000-0002-0587-9355
Forrest CollmanAllen Institute for Brain Science, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-0280-7022
H Sebastian SeungPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA. sseung@princeton.edu.ORCID http://orcid.org/0000-0002-8591-6733
David W TankPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA. dwtank@princeton.edu.ORCID http://orcid.org/0000-0002-9423-4267

Funding

BRAIN CONNECTS: A Center for High-throughput Integrative Mouse ConnectomicsUM1NS132250 · NINDS · HARVARD UNIVERSITY · PI Jeff W Lichtman · 2023 to 2026
$24.9M
Project-003UM1NS132253 · NINDS · ALLEN INSTITUTE · PI Forrest Christie Collman, Nuno Macarico da Costa · 2023 to 2026
$24.8M
P5: Mechanistic Multi-Region Brain ModelsU19NS132720 · NINDS · PRINCETON UNIVERSITY · PI Ilana Witten · 2023 to 2026
$21.5M
Structure and Function of a Cubic Millimeter of Cortex: Crowdsourcing for Proofreading and DiscoveryRF1MH123400 · NIMH · PRINCETON UNIVERSITY · PI SEUNG, HYUNJUNE SEBASTIAN · 2020 to 2020
$6.4M
High-throughput parallel transmission electron microscopy systemS10OD023602 · OD · PRINCETON UNIVERSITY · PI SEUNG, HYUNJUNE SEBASTIAN · 2018 to 2018
$2.0M
Circuit structure of cognitive maps in the hippocampusK99NS135650 · NINDS · PRINCETON UNIVERSITY · PI ZHENG, ZHIHAO · 2024 to 2025
$277k
NIH HHS S10 OD023602NIMH NIH HHS RF1 MH123400NINDS NIH HHS K99 NS135650NINDS NIH HHS U19 NS132720NINDS NIH HHS UM1 NS132250NINDS NIH HHS UM1 NS132253U.S. Department of Health & Human Services | National Institutes of Health (NIH) K99 NS135650U.S. Department of Health & Human Services | National Institutes of Health (NIH) RF1 MH123400U.S. Department of Health & Human Services | National Institutes of Health (NIH) S10OD023602U.S. Department of Health & Human Services | National Institutes of Health (NIH) U19 NS132720U.S. Department of Health & Human Services | National Institutes of Health (NIH) UM1 NS132250U.S. Department of Health & Human Services | National Institutes of Health (NIH) UM1 NS132253
6 · The paper itself

Abstract

The mossy fiber (MF) connections to pyramidal cells in hippocampal CA3 are thought to participate in pattern separation, pattern completion and memory encoding, yet no large-scale neuronal wiring diagram exists for these connections. We assembled a 3D electron microscopy volume (~1 × 1 × 0.1 mm

Indexed as

CA3 Region, HippocampalConnectomeMossy Fibers, HippocampalNeural InhibitionPyramidal CellsAnimalsInterneuronsMaleMiceMice, Inbred C57BL

Identifiers

PMID42557444
PMCPMC13533834

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.