Evidence map›Paper›PMID 42557365›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Vasopressin for hemodynamic support in neonates: current evidence and clinical applications.

Aimann Surak, Mohamed Sewidan, Mimi T Y Kuan, Megan Kennedy, Manoj Kumar, Joseph Y Ting

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In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aimann SurakDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.ORCID http://orcid.org/0000-0003-3477-3741
Mohamed SewidanDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Mimi T Y KuanDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.ORCID http://orcid.org/0000-0002-4751-6579
Megan KennedyGeoffrey & Robyn Sperber Health Sciences Library, University of Alberta, Edmonton, AB, Canada.
Manoj KumarDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Joseph Y TingDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada. yukjosep@ualberta.ca.ORCID http://orcid.org/0000-0002-5246-8823

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo systematically map and synthesize the available evidence on the use of vasopressin for hemodynamic support in neonates. STUDY

designWe conducted a scoping review to synthesize available data on indications, dosing, clinical effects, and safety.

resultsTwelve studies were included (one randomized trial, eleven observational), encompassing heterogeneous neonatal populations. Vasopressin was primarily used as rescue therapy in refractory shock, including sepsis, persistent pulmonary hypertension of the newborn, and congenital diaphragmatic hernia. Dosing regimens varied widely. Most studies reported improvements in mean arterial blood pressure, with some demonstrating reduced vasoactive support and improved oxygenation. Effects on urine output were variable. Safety reporting was inconsistent; hyponatremia was the most commonly described adverse event, while serious ischemic complications were rarely reported.

conclusionVasopressin may improve short-term hemodynamic parameters, but evidence is limited and heterogeneous, with insufficient data to guide optimal use.

Identifiers

PMID42557365

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.