Evidence map›Paper›PMID 42557330›Full record

ArticleNature2026

ZFP36L2 orchestrates stress-adaptive plasticity in regeneration and cancer.

Qingwen Jiang, Manisha S Raghavan, Aileen M Rodriguez, Morgan Lallo, Cyrus L Tam, Saskia Hartner, Britney Forsyth, Ahmed Mahmoud, Fabian Zincke, Huiyong Zhao and 20 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Qingwen JiangMolecular Pharmacology Program, Sloan Kettering Institute, New York, NY, USA.ORCID http://orcid.org/0000-0002-1714-6343
Manisha S RaghavanMolecular Pharmacology Program, Sloan Kettering Institute, New York, NY, USA.ORCID http://orcid.org/0009-0004-5247-4846
Aileen M RodriguezMolecular Pharmacology Program, Sloan Kettering Institute, New York, NY, USA.
Morgan LalloHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Cyrus L TamComputational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Saskia HartnerMolecular Pharmacology Program, Sloan Kettering Institute, New York, NY, USA.ORCID http://orcid.org/0009-0006-1030-1191
Britney ForsythHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ahmed MahmoudMolecular Pharmacology Program, Sloan Kettering Institute, New York, NY, USA.
Fabian ZinckeMolecular Pharmacology Program, Sloan Kettering Institute, New York, NY, USA.
Huiyong ZhaoAntitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Andrew MoormanComputational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Sasha BalkaranMolecular Pharmacology Program, Sloan Kettering Institute, New York, NY, USA.ORCID http://orcid.org/0000-0001-9991-6649
Kathleen LuckettMolecular Pharmacology Program, Sloan Kettering Institute, New York, NY, USA.
Jura PintarMolecular Pharmacology Program, Sloan Kettering Institute, New York, NY, USA.
Yevgeniy RominMolecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Eric ChanMolecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Anthony SantellaMolecular Cytology Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-5696-0591
Bernadette MödlMolecular Pharmacology Program, Sloan Kettering Institute, New York, NY, USA.
Farheen ShahDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Ilyes BaaliComputational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Michael G KharasMolecular Pharmacology Program, Sloan Kettering Institute, New York, NY, USA.ORCID http://orcid.org/0000-0002-1165-6991
Elisa de StanchinaAntitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Nil UrganciDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jinru ShiaDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-4351-2511
Dana Pe'erComputational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Francisco Sanchez-VegaDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-2990-4893
Richard KocheCenter for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-6820-5083
Quaid MorrisComputational and Systems Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-2760-6999
Joseph M ChanHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-5249-7395
Karuna GaneshMolecular Pharmacology Program, Sloan Kettering Institute, New York, NY, USA. ganeshk@mskcc.org.ORCID http://orcid.org/0000-0002-4948-1082

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
Weill Cornell/Rockefeller/Sloan Kettering MST ProgramT32GM152349 · NIGMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI KATHARINE C HSU · 2024 to 2026
$6.6M
Dissecting the Functional Consequences of Mutations in ZFP36L2 on Tumor Progression and Inflammation in the Tumor Immune Microenvironment of Colorectal CancerF30CA288018 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Kathleen Luckett · 2024 to 2026
$164k
NCI NIH HHS F30 CA288018NCI NIH HHS P30 CA008748NIGMS NIH HHS T32 GM152349
6 · The paper itself

Abstract

Phenotypic plasticity is a hallmark of cancer

Indexed as

Cell PlasticityColorectal NeoplasmsRegenerationStress, PhysiologicalTristetraprolin3' Untranslated RegionsAnimalsCell DedifferentiationCell DifferentiationCell LineageColonFemaleHumansMaleMiceNeoplasm Metastasis3' Untranslated RegionsLgr5 protein, mouseReceptors, G-Protein-CoupledRNA, MessengerTristetraprolin

Identifiers

PMID42557330
PMCPMC13600930

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.