ArticleNature2026
FNIP1 variants are associated with favourable metabolism in 1 million humans.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- One million exomes identify FNIP1 as a metabolic brake.Trends in genetics : TIG · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
62 authors.
George Hindy *Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0002-7257-9299
Rene C Adam *Regeneron Pharmaceuticals, Tarrytown, NY, USA.ORCID http://orcid.org/0009-0003-7824-5331
Olukayode SosinaRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0003-2120-0338
Dwaine PryceRegeneron Pharmaceuticals, Tarrytown, NY, USA.
David BlairRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Joseph HermanRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Joseph LeeRegeneron Pharmaceuticals, Tarrytown, NY, USA.
Peter DornbosRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Ernst MayerhoferRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Arthur GillyRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Charleen HuntRegeneron Pharmaceuticals, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0003-0537-862X
Benjamin GeraghtyRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Karl LandheerRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0001-5012-3007
Liron GanelRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0002-8762-622X
Antoine BaldassariRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Chuanyi ZhangRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0002-6359-0904
Ivory MintahRegeneron Pharmaceuticals, Tarrytown, NY, USA.
Daphne SunRegeneron Pharmaceuticals, Tarrytown, NY, USA.
Angel CoppolaRegeneron Pharmaceuticals, Tarrytown, NY, USA.
Kyle BrownRegeneron Pharmaceuticals, Tarrytown, NY, USA.
Tram NguyenRegeneron Pharmaceuticals, Tarrytown, NY, USA.
Xin XiaRegeneron Pharmaceuticals, Tarrytown, NY, USA.
Regeneron Genetics Center
GHS-RGC DiscovEHR Collaboration
Penn Medicine Biobank
Colorado Center for Personalized Medicine
Mayo Clinic-RGC Project Generation
Mexico City Prospective Study
Malmö Diet and Cancer Study
Indiana University School of Medicine (Indiana-CLDB)
UCLA-RGC ATLAS Collaboration
Mount Sinai Million Health Discoveries Program
UTSW-Dallas Biobank
South Asia Biobank Study
Daniel J RaderDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9245-9876
Olle MelanderDepartment of Clinical Sciences Malmö, Lund University, Malmö, Sweden.
Christopher D StillGeisinger Obesity Institute, Geisinger Health System, Danville, PA, USA.ORCID http://orcid.org/0000-0001-8006-8483
Jaime BerumenFaculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.ORCID http://orcid.org/0000-0001-6707-3317
Pablo Kuri-MoralesProyecto OriGen, Tecnológico de Monterrey, Monterrey, Mexico.ORCID http://orcid.org/0000-0002-0704-9507
Jesus Alegre-DíazFaculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.ORCID http://orcid.org/0000-0001-9390-3871
Jason M TorresNuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-7537-7035
Jonathan R EmbersonNuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0001-7792-9422
Rory CollinsNuffield Department of Population Health, University of Oxford, Oxford, UK.
Roberto Tapia-ConyerFaculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.ORCID http://orcid.org/0000-0003-3814-2904
Suganthi BalasubramanianRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0003-2243-5948
Marcus B JonesRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Michelle G LeBlancRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Andrew J MurphyRegeneron Pharmaceuticals, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0003-4152-4081
Christos A KyratsousRegeneron Pharmaceuticals, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0002-2596-2906
John D OvertonRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Jeffrey G ReidRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0001-8645-4713
Goncalo R AbecasisRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0003-1509-1825
Jonathan MarchiniRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0003-0610-8322
Cristen WillerRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0001-5645-4966
George D YancopoulosRegeneron Pharmaceuticals, Tarrytown, NY, USA.
Mark W SleemanRegeneron Pharmaceuticals, Tarrytown, NY, USA.
Jonas BovijnRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Adam LockeRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0001-6227-198X
Aris BarasRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.ORCID http://orcid.org/0000-0002-6830-3396
Niek VerweijRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.
Viktoria GusarovaRegeneron Pharmaceuticals, Tarrytown, NY, USA. viktoria.gusarova@regeneron.com.ORCID http://orcid.org/0000-0002-2266-783X
Luca A LottaRegeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA. luca.lotta@regeneron.com.ORCID http://orcid.org/0000-0002-2619-5956
Funding
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Lila J. Rutten · 1985 to 2026
$151.3MUse of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancerP50CA136393 · NCI · MAYO CLINIC ROCHESTER · PI SCOTT H KAUFMANN · 2009 to 2026
$37.0MRelating Molecular Subgroups of Endometriosis-Associated Ovarian Cancers to Survival and RiskR01CA248288 · NCI · MAYO CLINIC ROCHESTER · PI Stacey J Winham · 2021 to 2026
$4.8MNCI NIH HHS P30 CA015083NCI NIH HHS P50 CA136393NCI NIH HHS R01 CA248288
Abstract
Altered energy metabolism is a shared driver across cardiometabolic diseases-the leading cause of death globally
Indexed as
Carrier ProteinsEnergy MetabolismGenetic VariationAdipose TissueAnimalsCardiovascular DiseasesCholesterol, HDLExome SequencingFemaleGene Knockdown TechniquesHepatocytesHumansLipid MetabolismLiverLysosomesMaleCarrier ProteinsCholesterol, HDLFNIP1 protein, humanTriglycerides
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What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.