Evidence map›Paper›PMID 42557316›Full record

ArticleNature2026

A compendium of next-generation patient-derived models for diverse cancers.

Dina ElHarouni, Mushriq Al-Jazrawe, Seongmin Choi, Merve Dede, Toshinori Hinoue, Sean A Misek, Heeju Noh, Luca Zanella, Yuen-Yi Tseng, Hayley E Francies and 48 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

58 authors.

Dina ElHarouni *Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Mushriq Al-Jazrawe *Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-4267-4236
Seongmin Choi *Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-9722-1800
Merve Dede *Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID http://orcid.org/0000-0002-0868-5863
Toshinori Hinoue *Van Andel Institute, Department of Epigenetics, Grand Rapids, MI, USA.
Sean A Misek *Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Heeju Noh *Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
Luca Zanella *Department of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-7955-0168
Yuen-Yi TsengBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Hayley E FranciesWellcome Sanger Institute, Cambridge, UK.
Dennis PlenkerCold Spring Harbor Laboratory Cancer Center, Cold Spring Harbor, New York, NY, USA.ORCID http://orcid.org/0000-0003-3895-4064
Cindy W KyiCenter for Cancer Genomics, NCI, Bethesda, MD, USA.
Julyann Perez-MayoralCenter for Cancer Genomics, NCI, Bethesda, MD, USA.
Megan J StineManagement Services, Calverton, MD, USA.
Eva Tonsing-CarterCenter for Cancer Genomics, NCI, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-4133-5566
Rachana AgarwalFrederick National Laboratory for Cancer Research, Frederick, MD, USA.
Jean Claude ZenklusenCenter for Cancer Genomics, NCI, Bethesda, MD, USA.
James M ClintonAmerican Type Culture Collection, Manassas, VA, USA.
Jennifer M SheltonNew York Genome Center, New York, NY, USA.
Timothy R ChuNew York Genome Center, New York, NY, USA.
William F HooperNew York Genome Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-0078-8921
Xavi LoinazBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Paula KeskulaBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Jordan TagleOregon Health & Science University, Department of Biomedical Engineering, Portland, OR, USA.ORCID http://orcid.org/0000-0002-0983-0495
Peyton C KuhlersDepartment of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Bahar TercanInstitute for Systems Biology, Seattle, WA, USA.
Sylvia F BojHUB Organoids, Merck, Utrecht, The Netherlands.
Alessandro VasciaveoCenter for Data Science and Artificial Intelligence, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-0205-9869
Lorenzo TomassoniDepartment of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.
James M CrawfordNorthwell Health, New Hyde Park, NY, USA.
Shawna WalshDepartment of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Claire SinaiDepartment of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Sonam BhatiaDepartment of Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0124-2621
Priya SrideviCold Spring Harbor Laboratory Cancer Center, Cold Spring Harbor, New York, NY, USA.
Hardik PatelCold Spring Harbor Laboratory Cancer Center, Cold Spring Harbor, New York, NY, USA.ORCID http://orcid.org/0009-0002-9242-1795
Maria Antonietta CeroneCancer Research Horizons, Therapeutic Innovation, Babraham Research Campus, Cambridge, UK.
HCMI Network
Kyle EllrottOregon Health & Science University, Department of Biomedical Engineering, Portland, OR, USA.ORCID http://orcid.org/0000-0002-6573-5900
Calvin J KuoDepartment of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-7427-5985
Olivier ElementoEnglander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-8061-9617
Semir BeyazCold Spring Harbor Laboratory Cancer Center, Cold Spring Harbor, New York, NY, USA.ORCID http://orcid.org/0000-0003-4730-4012
Vincenzo CorboDepartment of Engineering for Innovation Medicine and ARC-Net Research Centre, University of Verona, Verona, Italy.ORCID http://orcid.org/0000-0002-6340-8009
David L SpectorCold Spring Harbor Laboratory Cancer Center, Cold Spring Harbor, New York, NY, USA.ORCID http://orcid.org/0000-0003-3614-4965
Rameen BeroukhimBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-6303-3609
Martin L FergusonCenter for Cancer Genomics, NCI, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-2050-4199
Andrew D CherniackBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-0470-0111
Peter W LairdVan Andel Institute, Department of Epigenetics, Grand Rapids, MI, USA.ORCID http://orcid.org/0000-0001-9117-3641
Nicolas RobineNew York Genome Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-5698-8183
Andrew McPhersonComputational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-5654-5101
Katherine A HoadleyDepartment of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-1216-477X
Mathew J GarnettWellcome Sanger Institute, Cambridge, UK.ORCID http://orcid.org/0000-0002-2618-4237
David A TuvesonCold Spring Harbor Laboratory Cancer Center, Cold Spring Harbor, New York, NY, USA.ORCID http://orcid.org/0000-0002-8017-2712
Andrea CalifanoDepartment of Systems Biology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-4742-3679
Paul T SpellmanDepartments of Medicine and Human Genetics, University of California Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0002-4810-0022
Keith L LigonBroad Institute of MIT and Harvard, Cambridge, MA, USA. Keith_Ligon@dfci.harvard.edu.ORCID http://orcid.org/0000-0002-7733-600X
Daniela S GerhardCenter for Cancer Genomics, NCI, Bethesda, MD, USA.
Louis M StaudtLymphoid Malignancies Branch, Center for Cancer Research, NCI, Bethesda, MD, USA. lstaudt@nci.nih.gov.
Jesse S BoehmBroad Institute of MIT and Harvard, Cambridge, MA, USA. boehm@mit.edu.ORCID http://orcid.org/0000-0002-6795-6336

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models

Indexed as

Models, BiologicalNeoplasmsBiocurationDNA MethylationEpigenesis, GeneticExomeGene Expression ProfilingGenome, HumanHumansOrganoids

Identifiers

PMID42557316
PMCPMC13581597

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.