ArticleNature2026
A dependency map enhanced with next-generation 3D cancer models.
Abstract read
In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
69 authors.
James V Neiswender *Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Samuel Maffa *Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0009-0008-8862-178X
Lisa Brenan *Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Dina ElHarouniBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Yejie YunBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Isabella BoyleBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-8138-1225
Kirsty WienandBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-9548-4420
Haider InamBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Tate BerteaBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Ashley AndersonBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-4004-8079
Megan WongBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0009-0000-4730-6232
Matias EnriquezBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Evan LenzBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0009-0006-5271-4306
Beatriz VillafrancaBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Nora ShanksBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Mary HagerBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Nia LloydBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0009-0009-3019-5738
Hannah ShadmanyBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Sarah J WieBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-3042-7577
Harry LiangBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Konnor YunghansBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0009-0000-3834-8297
Xiaomeng ZhangBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-8536-6460
Lauren GoldenBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Hannah HarrisBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Serena DayBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Philip MontgomeryBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-2633-1081
Samantha StokesBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Ross M GiglioDepartment of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6208-8517
Cynthia HajalDepartment of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.
James R WhittleDepartment of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.
Guadalupe GarciaDepartment of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-8673-2303
Caitlin E MillsLaboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2608-4084
Mehdi TouatDepartment of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.
Kristine PeltonDepartment of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.
Hongyu LiDepartment of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.
Prem Sai PrabhakarDepartment of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.
Sonja HerterDepartment of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0009-0007-9841-5085
Zoe Hoffmann KamratDepartment of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0009-0001-5087-0587
Dan GuiBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Julien DillyBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-4006-5285
Chen Khuan WongHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Jimmy A GuoBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Sangita PalBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Yossef BaidiBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Ryan JohnstonBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Daniel D BrownInstitute for Precision Medicine, University of Pittsburgh and UPMC, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-7410-9514
Sonam BhatiaDepartment of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0124-2621
Peter S WinterBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Srivatsan RaghavanBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-5374-9918
Rameen BeroukhimBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-6303-3609
Eva ColasGroup of Biomedical Research in Gynecology, Vall d'Hebron Institute of Research (VHIR), Instituto de Investigación Sanitaria Hospital Universitari Vall d'Hebron (IIS IR-HUVH), Universitat Autònoma de Barcelona, CIBERONC, Barcelona, Spain.
David L SpectorCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.ORCID http://orcid.org/0000-0003-3614-4965
Adam J BassBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-8193-4758
Peter K SorgerLaboratory of Systems Pharmacology, Harvard Program in Therapeutic Science, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3364-1838
Yu ChenHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-0171-3884
Sarah J HillDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9199-9459
Steffi OesterreichUPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-2537-6923
Adrian V LeeInstitute for Precision Medicine, University of Pittsburgh and UPMC, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-9917-514X
Himisha BeltranDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3259-2226
Jesse S BoehmBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-6795-6336
Yuen-Yi TsengBroad Institute of MIT and Harvard, Cambridge, MA, USA.
David E RootBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-5122-861X
William C HahnBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-2840-9791
Andrew J AguirreBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-0701-6203
Catarina D CampbellBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Keith L LigonBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-7733-600X
Joshua M DempsterBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-3634-9576
Tsukasa ShibueBroad Institute of MIT and Harvard, Cambridge, MA, USA. tshibue@broadinstitute.org.ORCID http://orcid.org/0000-0002-3665-6154
Francisca VazquezBroad Institute of MIT and Harvard, Cambridge, MA, USA. vazquez@broadinstitute.org.ORCID http://orcid.org/0000-0002-2857-4685
Funding
X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4MNCI NIH HHS P30 CA008748
Abstract
Despite advances in precision oncology, effective personalized treatments are still lacking for most patients with cancer
Indexed as
Models, BiologicalNeoplasmsAnimalsBiomarkers, TumorCell Line, TumorCRISPR-Cas SystemsGene Expression Regulation, NeoplasticGenomicsHumansMultiomicsSpheroids, CellularBiomarkers, Tumor
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.