ArticleRMD open2026
Influence of initial axial involvement on the phenotypic evolution of axial spondyloarthritis: 10-year data from the DESIR cohort.
Article in RMD open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo investigate whether the initial location of inflammatory axial pain in axial spondyloarthritis (axSpA) is associated with the development of peripheral or extra-rheumatological manifestations over a 10-year period.
methodsData were drawn from the 10-year prospective DESIR
resultsAmong 662 included patients, 94 (14.2%) had cervicothoracic, 466 (70.3%) had lumbosacral and 102 (15.5%) had diffuse involvement at baseline. Patients with diffuse involvement were older, had a lower education level, a lower prevalence of prior dactylitis and higher modified Stoke Ankylosing Spondylitis Spinal Score compared with other groups. Over 10 years, diffuse involvement was independently associated with an increased risk of developing arthritis (HR 1.61; 95% CI 1.15 to 2.25) compared with lumbosacral involvement. No other significant associations were observed.
conclusionDiffuse initial axial involvement identifies a subgroup of patients with axSpA at increased risk of developing peripheral arthritis. This finding has practical implications for clinicians in early risk stratification, patient counselling and interpretation of therapeutic trial outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.