Evidence map›Paper›PMID 42556714›Full record

ArticleNeuropharmacology2026

Sex-specific differences in endocannabinoid regulation of cocaine-evoked dopamine in the medial nucleus accumbens shell.

Andrew D Gaulden, Kristin Chase, Jayme R McReynolds

Abstract read
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In one paragraph

Article in Neuropharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Andrew D GauldenDepartment of Pharmacology, Physiology, and Neurobiology, University of Cincinnati College of Medicine, 2120 E. Galbraith Rd, Cincinnati, OH, 45237, USA; Division of Child and Adolescent Psychiatry, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Kristin ChaseDepartment of Pharmacology, Physiology, and Neurobiology, University of Cincinnati College of Medicine, 2120 E. Galbraith Rd, Cincinnati, OH, 45237, USA.
Jayme R McReynoldsDepartment of Pharmacology, Physiology, and Neurobiology, University of Cincinnati College of Medicine, 2120 E. Galbraith Rd, Cincinnati, OH, 45237, USA; UC/UC Health Addiction Center/Research, University of Cincinnati College of Medicine, 3230 Eden Ave, Cincinnati, OH, 45267, USA. Electronic address: jayme.mcreynolds@uc.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endocannabinoid (eCB) signaling is a key regulator of reward-related dopaminergic signaling, particularly in response to drugs of abuse, such as cocaine. To date, our understanding of this mechanism has primarily been limited to male subjects. Prior work establishes that female cocaine users have more adverse outcomes, and female rats show greater sensitivity to cannabinoid type 1 receptor (CB1R) regulation of cocaine self-administration. Therefore, we hypothesize that female rats exhibit enhanced eCB regulation of cocaine-evoked dopamine (DA). We used in vivo fiber photometry recording of the dopamine biosensor, dLight 1.3b, in the nucleus accumbens medial shell (NAc

Indexed as

CocaineDopamineDopamine Uptake InhibitorsEndocannabinoidsNucleus AccumbensSex CharacteristicsAnimalsArachidonic AcidsFemaleGlyceridesMaleRatsRats, Sprague-DawleyReceptor, Cannabinoid, CB1Arachidonic AcidsCocaineDopamineDopamine Uptake InhibitorsEndocannabinoidsGlyceridesglyceryl 2-arachidonateReceptor, Cannabinoid, CB1CocaineDopamineEndocannabinoidNucleus accumbensSex differences

Identifiers

PMID42556714

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.