Evidence map›Paper›PMID 42556341›Full record

ArticleCell reports. Medicine2026

Gut commensal Olsenella profusa promotes endometriosis via lysophosphatidylcholine metabolite.

Yuying Chen, Ziwei Zhou, Biqi Huang, Xunjie Xie, Yuzhen Cao, Shanshui Zeng, Bingyu Li, Fangbo Xia, Li Peng, Jiarui Liang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yuying ChenObstetrics and Gynecology Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China; Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Ziwei ZhouMicrobiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Biqi HuangObstetrics and Gynecology Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Xunjie XieMicrobiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Yuzhen CaoObstetrics and Gynecology Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Shanshui ZengMicrobiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Bingyu LiMicrobiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Fangbo XiaMicrobiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Li PengObstetrics and Gynecology Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Jiarui LiangMicrobiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Shulei ChenMicrobiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Haojing LiuDepartment of Health Management, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
Hongwei ZhouMicrobiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China; Shenzhen Key Laboratory of Gastrointestinal Microbiota and Disease, Department of Gastroenterology, Gynecology and Obstetrics, and Laboratory Medicine, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, China; State Key Laboratory of Multi-organ Injury Prevention and Treatment, Southern Medical University, Guangzhou, Guangdong, China; Guangdong Provincial Clinical Research Center for Laboratory Medicine, Guangzhou, Guangdong, China. Electronic address: hzhou@smu.edu.cn.
Ying MaObstetrics and Gynecology Medical Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China. Electronic address: mayingwuzhuoyi@126.com.
Dongxin ZhangMicrobiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China; Guangdong Provincial Clinical Research Center for Laboratory Medicine, Guangzhou, Guangdong, China. Electronic address: zhangdongxin@smu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endometriosis (EM) is an intractable gynecological condition with uncertain etiology. Gut microbiota have been increasingly implicated in EM, yet the underlying mechanisms remain unclear. Here, we identify a gut microbe-metabolite-uterus axis that drives EM pathogenesis. In our EM cohort, we found that the gut bacterium Olsenella profusa (O. profusa) and metabolite lysophosphatidylcholine (LPC) (16:0) were significantly enriched in patients with EM and showed positive correlation. In a mouse model of EM, oral gavage with O. profusa accelerated ectopic lesion growth through producing LPC (16:0) via its phospholipase, an effect recapitulated by LPC (16:0) alone. Mechanistically, LPC (16:0) promotes EM by inducing endometrial stromal cell proliferation and migration through the secreted phosphoprotein 1 (SPP1)-PI3K-AKT pathway. Moreover, O. profusa and LPC (16:0) show potential as early diagnostic biomarkers. This study suggests a causal role for the gut O. profusa-LPC (16:0) metabolic axis in EM progression and identifies promising targets for diagnosis and therapy.

Indexed as

EndometriosisGastrointestinal MicrobiomeLysophosphatidylcholinesAnimalsCell MovementCell ProliferationDisease Models, AnimalFemaleHumansMicePhosphatidylinositol 3-KinasesSignal TransductionLysophosphatidylcholinesPhosphatidylinositol 3-Kinasesendometriosisgut microbiotaLPC (16:0)Olsenella profusaSPP1

Identifiers

PMID42556341
PMCPMC13522808

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.