Evidence map›Paper›PMID 42556339›Full record

ArticleCell reports. Medicine2026

Universal catalytic endothelial lineage nanovesicles for targeting and rescuing ischemic endothelium.

Hongyi Jiang, Yumeng Wang, Haosheng Huang, Liang Zhu, Hanting Shen, Liting Jiang, Chihao Lin, Huangyi Fang, Gang Zheng, Junfeng Shi and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Hongyi JiangDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, Zhejiang, China; The Second Clinical School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China; Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, China.
Yumeng WangDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, Zhejiang, China; The Second Clinical School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China; Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Haosheng HuangDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, Zhejiang, China; The Second Clinical School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Liang ZhuDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, Zhejiang, China; The Second Clinical School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Hanting ShenDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, Zhejiang, China; The Second Clinical School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Liting JiangDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, Zhejiang, China; The Second Clinical School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Chihao LinDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, Zhejiang, China; The Second Clinical School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Huangyi FangDepartment of Neurosurgery, Wenzhou Municipal Key Laboratory of Neurodevelopmental Pathology and Physiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
Gang ZhengDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, Zhejiang, China; The Second Clinical School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Junfeng ShiThe Affiliated XiangTan Central Hospital of Hunan University, School of Biomedical Sciences, Hunan University, Changsha, Hunan, China.
Xinghe XueDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, Zhejiang, China; The Second Clinical School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Jilong WangWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, China.
Jian LinDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, Zhejiang, China; The Second Clinical School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address: linj0208@163.com.
Junjie DengWenzhou Institute, University of Chinese Academy of Sciences, Wenzhou, Zhejiang, China. Electronic address: j.deng@ucas.ac.cn.
Liang ChenDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, Zhejiang, China; The Second Clinical School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address: breakingsunshine@wmu.edu.cn.
Xiaoyun PanDepartment of Orthopedics, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China; Key Laboratory of Orthopedics of Zhejiang Province, Wenzhou, Zhejiang, China; The Second Clinical School of Medicine, Wenzhou Medical University, Wenzhou, Zhejiang, China. Electronic address: xiaoyunpan@wmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular endothelial dysfunction drives major ischemic diseases, yet current nanovesicle therapies lack precise targeting and fail to counteract severe oxidative stress. Here, we engineer a universal, dual-targeting therapeutic platform by functionalizing nanovesicles from induced pluripotent stem cell (iPSC)-derived endothelial cells with antioxidant ceria nanozymes (CeO

Indexed as

Endothelial CellsEndothelium, VascularIschemiaAngiogenesisAnimalsCatalysisCeriumHumansInduced Pluripotent Stem CellsMiceNeovascularization, PhysiologicReactive Oxygen Speciesceric oxideCeriumReactive Oxygen Speciesbiomimetic nanovesiclesceria nanozymesdual-targetingendothelial dysfunctionischemic diseases

Identifiers

PMID42556339
PMCPMC13522786

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.