ArticleScience advances2026
Sharp nanothorn-equipped ionogel microrobots for targeted periodontitis therapy.
Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Periodontitis necessitates targeted therapy due to its high prevalence, progressive tissue destruction, and systemic disease links. Conventional mechanical debridement and pharmacological treatments are limited by complex periodontal barriers, including viscous crevicular fluid and resilient biofilms, which impede bacterial eradication and drug delivery. Here, we engineered magnetically actuated microrobots with gold nanothorns for disrupting biofilms and penetrating mucus barriers. Fabricated by encapsulating curcumin in antibacterial ionogel microspheres with asymmetric magnetic deposition and nanothorn functionalization, these microrobots enabled precise magnetic navigation in viscous media, while penetrating a biomimetic mucus analog, enhancing periodontal retention, and mechanically dislodging biofilms. Furthermore, ethanol-responsive release of curcumin enhanced its bioavailability, thereby scavenging free radicals and modulating macrophage phenotypes to alleviate inflammation. Guided by a toothbrushing-inspired handheld magnetic controller, microrobots evaluated using in vivo murine models demonstrated reduced inflammation, inhibited bone resorption, improved tissue health, and oral microbiota remodeling toward ecological balance, showing promise for targeted periodontitis therapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.