ArticleScience advances2026
Nucleic acid probe-functionalized self-powered sensor for detection of biomarkers in clinical urine samples.
Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Triboelectric nanogenerator (TENG)-based self-powered biosensors can reduce ecological risks from energy storage device disposal and complex electronics manufacturing, offering cost-effective and eco-friendly diagnostic methods. However, in the intricate charge environment of urine, existing devices are difficult to specifically capture targets and produce recognizable changes in surface charge and the resulting electrical signals, leading to insufficient detection specificity and sensitivity. Herein, for the first time, the problem is addressed by a TENG-based self-powered sensor for clinical urine detection. Self-charged nucleic acid probe modification and targeted conformational change induce specific surface charge variation; regulating system ionic strength matches Debye length with probe conformational scale to maximize this variation. A double-electrode device efficiently converts surface charge changes into distinct output signals, boosting sensing performance in intricate charged environments. This sensor achieves sensitive detection of ATP (269 pM) and miR-21 (328 pM) in artificial urine, effectively monitors urinary ATP elevation in cystitis patients, showing potential for low-cost, easy-to-operate home health monitoring, promoting health equity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.