Evidence map›Paper›PMID 42555712›Full record

ArticleScience advances2026

A metabolite morphogen coordinates multicellular development in

Taylor B Updegrove, Vani Pande, Fukang She, Michael C Gilmore, Vivek Anantharaman, David M Stevenson, Daniel Amador-Noguez, L Aravind, Felipe Cava, Jiji Chen and 2 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Taylor B UpdegroveLaboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-9763-3618
Vani PandeLaboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Fukang SheDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0009-0008-8633-252X
Michael C GilmoreThe Laboratory for Molecular Infection Medicine Sweden, Umeå Center for Microbial Research, Science for Life Laboratory (SciLifeLab), Department of Molecular Biology, Umeå University, Umeå, Sweden.ORCID 0000-0002-6848-5134
Vivek AnantharamanComputational Biology Branch, Division of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-8395-0009
David M StevensonDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA.
Daniel Amador-NoguezDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0002-3568-3070
L AravindComputational Biology Branch, Division of Intramural Research, National Library of Medicine, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-0771-253X
Felipe CavaThe Laboratory for Molecular Infection Medicine Sweden, Umeå Center for Microbial Research, Science for Life Laboratory (SciLifeLab), Department of Molecular Biology, Umeå University, Umeå, Sweden.ORCID 0000-0001-5995-718X
Jiji ChenAdvanced Imaging and Microscopy Resource, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-4426-3035
Jue D WangDepartment of Bacteriology, University of Wisconsin-Madison, Madison, WI, USA.ORCID 0000-0003-1503-170X
Kumaran S RamamurthiLaboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-2335-3568

Funding

The critical roles of (p)ppGpp in homeostasis and antibiotic tolerance in Gram positive bacteriaR35GM127088 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Jue D. Wang · 2018 to 2026
$3.9M
NIGMS NIH HHS R35 GM127088
6 · The paper itself

Abstract

The transition from unicellular to multicellular growth requires diversification of cellular functions within genetically identical populations. In

Indexed as

Bacillus subtilisBacterial ProteinsBiofilmsCell WallGlycerolLipopolysaccharidesSpores, BacterialTeichoic AcidsBacterial ProteinsGlycerolLipopolysaccharideslipoteichoic acidTeichoic Acids

Identifiers

PMID42555712
PMCPMC13440414

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.