Evidence map›Paper›PMID 42555689›Full record

SynthesisThe Indian journal of medical research2026

Health risks of arsenic and chromium in groundwater and surface water in India: A systematic review.

Vartika Sakalkar, Shipra Singh, Ekta Gupta, Anuj Kumar, Pramod Kumar, Chander Prakash Yadav

Abstract readSystematic Review
In one paragraph

Synthesis in The Indian journal of medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Vartika SakalkarDepartment of Public Health, Indian Institute of Public Health, Gandhinagar, Gujarat, India.
Shipra SinghDepartment of Public Health, G.D Goenka University, Gurugram, Haryana, India.
Ekta GuptaDepartment of Clinical Oncology, ICMR-National Institute of Cancer Prevention and Research, Noida, Uttar Pradesh, India.
Anuj KumarDepartment of Molecular Biology, ICMR-National Institute of Cancer Prevention and Research, Noida, Uttar Pradesh, India.
Pramod KumarDepartment of Molecular Biology, ICMR-National Institute of Cancer Prevention and Research, Noida, Uttar Pradesh, India.
Chander Prakash YadavDepartment of Epidemiology and Biostatistics, ICMR-National Institute of Cancer Prevention and Research, Noida, Uttar Pradesh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and objectives India ranks third in global cancer incidence. Groundwater often carries undetectable contaminants such as arsenic, a highly toxic element, and chromium, a probable carcinogen. This systematic review aims to identify patterns of arsenic and chromium exposure in Indian population through groundwater and surface water, and the resulting health effects, including cancer and other non-communicable diseases. Methods A comprehensive search was conducted in PubMed, Embase, and Scopus for English-language studies from inception to January 8, 2025. Studies assessing health effects of arsenic or chromium in groundwater or surface were included. After screening the articles, data on key health risk indices: hazard quotient (HQ) and carcinogenic risk, were extracted and categorised by standard thresholds. Heat maps and violin plots were used to represent health risk levels across studies and regions. Joanna Briggs Institute (JBI) critical appraisal tool was used for quality assessment. Results A total of 1259 articles were identified, with 63 included studies. All reported studies presented a low risk of bias. Arsenic ingestion indicated non-carcinogenic risks in 49% of adult and 60% of child-focused studies. Chromium ingestion risks were lower, reported in 12% and 14% of adult and children-focused studies, respectively. Carcinogenic risk was higher for both metals, particularly through ingestion. Higher non-carcinogenic risk was reported from groundwater than surface water, especially via dermal exposure in children. Affected regions were Punjab, West Bengal, Haryana, Delhi, Uttarakhand, and Jammu and Kashmir. Interpretation and conclusions Groundwater arsenic contamination poses a major public health threat in India, while evidence on chromium ingestion risks are limited.

Indexed as

ArsenicChromiumGroundwaterNeoplasmsWater Pollutants, ChemicalEnvironmental ExposureHumansIndiaArsenicChromiumWater Pollutants, ChemicalArsenicCarcinogenic riskChromiumGroundwaterIndiaNon-carcinogenic riskSurface water

Identifiers

PMID42555689
PMCPMC13466804

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.