ArticleACS omega2026
Effect of Noscapine Hydrochloride on the Near-Infrared Optical Properties of Indocyanine Green.
Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
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Abstract
Indocyanine Green (ICG) is a widely used near-infrared fluorophore in biomedical imaging and therapy due to its strong light absorption and effective heat conversion abilities. Recently, combination of chemotherapy with PTT (chemo-PTT) has emerged as a promising approach to improve cancer treatment effectiveness. This study investigates the interaction between Noscapine Hydrochloride (Np.HCl), a benzyl isoquinoline alkaloid with potential anticancer effects, and ICG, with a specific focus on its influence on ICG's optical properties. The findings indicate that Np.HCl promotes J-aggregation even at low concentrations, with aggregation intensity increasing proportionally to Np.HCl concentrations. A simple and reproducible method has been developed to synthesize these J-aggregates (IJAs) using FDA-approved agents, Np.HCl and ICG, highlighting their potential applications in improving chemotherapy outcomes. Spectral analysis revealed the presence of both blue and red shifts, depending on the dye concentration, indicating molecular interactions between Np.HCl and IGs, which were quantitatively assessed through Gaussian fitting. Additionally, Stern-Volmer plots were used to analyze the quenching dynamics and interaction mechanism. Further, cytotoxicity studies have been performed on H1299 cells, which revealed IC
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