ArticleJournal of Taibah University Medical Sciences2026
Determining the concentration of golden sea cucumber (
Article in Journal of Taibah University Medical Sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Traumatic oral ulcers are common lesions that may interfere with oral function and quality of life. Golden sea cucumber ( Methods: Twenty male Wistar rats were randomly divided into four groups: control, 20%, 40%, and 80% golden sea cucumber extract gel groups. Traumatic ulcers were induced on the lower labial mucosa using a heated burnisher. The treatment groups received topical application of the extract gel once daily. Histopathological evaluations were performed on days 4 and 7 post-ulcer induction. The observed parameters included macrophage count, mast cell count, angiogenesis, collagen density, and re-epithelialization. Statistical analysis was performed using one-way ANOVA followed by Tukey's post hoc test, with p < 0.05 considered statistically significant. Results: The 40% concentration group demonstrated higher angiogenesis compared with the other groups during the early healing phase. Meanwhile, the 80% concentration group showed greater macrophages, epithelial thickness, and collagen density during the proliferative phase. Significant differences were observed among treatment groups in several histological parameters (p < 0.05), indicating enhanced wound healing activity following golden sea cucumber extract administration. Conclusion:
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