Evidence map›Paper›PMID 42554978›Full record

ArticleJournal of the National Cancer Institute2026

Examining the role of extrachromosomal DNA in lung cancer.

Azhar Khandekar, Phuc H Hoang, Jens Luebeck, Marcos Díaz-Gay, Wei Zhao, John P McElderry, Caleb Hartman, Mona Miraftab, Olivia W Lee, Kara M Barnao and 23 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the National Cancer Institute, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

33 authors.

Azhar KhandekarDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Phuc H HoangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Jens LuebeckDepartment of Computer Science, University of California San Diego, La Jolla, CA, USA.
Marcos Díaz-GayDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Wei ZhaoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
John P McElderryDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Caleb HartmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Mona MiraftabDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Olivia W LeeDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Kara M BarnaoDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Kristine JonesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Amy HutchinsonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Belynda HicksDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Erik N BergstromDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Yang YangBen May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.
Martin A NowakDepartment of Mathematics, Harvard University, Cambridge, MA, USA.
Nathaniel RothmanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Angela C PesatoriDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Dario ConsonniFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Robert HomerDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA.
Marina K BaineDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Lynette M ShollBrigham and Women's Hospital, Boston, MA, USA.
Philippe JoubertInstitut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Canada.
Charles LeducCentre Hospitalier de l'Université de Montréal, Montreal, Canada.
William D TravisDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Soo-Ryum YangDepartment of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Qing LanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
David C WedgeManchester Cancer Research Centre, The University of Manchester, Manchester, UK.
Lixing YangBen May Department for Cancer Research, The University of Chicago, Chicago, IL, USA.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Tongwu ZhangDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Ludmil B AlexandrovDepartment of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA.
Maria Teresa LandiDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI John L. Cleveland · 1998 to 2026
$93.5M
Genetic EpidemiologyZIACP005803 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI GOLDSTEIN, ALISA · 2009 to 2025
$24.8M
Studies of Genetic and Environmental EpidemiologyZIACP101231 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI LANDI, MARIA · 2018 to 2025
$23.6M
The Boston Lung Cancer Survival CohortU01CA209414 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI David C Christiani · 2017 to 2026
$12.2M
Role of hypernutrition and metabolic stress in non-alcoholic steatohepatitis (NASH) driven hepatocellular carcinoma (HCC)P01CA281819 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI Pablo Tamayo · 2024 to 2026
$9.2M
Detecting Mutational Signatures of Environmental Mutagens in Heathy Individuals for Personalized Cancer PreventionR01ES032547 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALEXANDROV, LUDMIL B · 2021 to 2025
$3.4M
Mapping immuno-genomic drivers of the head and neck precancer invasive-disease transitionU01CA290479 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Jorge Silvio Gutkind · 2023 to 2026
$3.1M
Comprehensive identification of germline-somatic interactionsR01CA269919 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Ludmil B Alexandrov, Hannah Kathryn Carter · 2022 to 2026
$2.2M
Intramural NIH HHS ZIA CP005803Intramural NIH HHS ZIA CP101231NCI NIH HHS P01 CA281819NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA269919NCI NIH HHS U01 CA209414NCI NIH HHS U01 CA290479NIEHS NIH HHS R01 ES032547
6 · The paper itself

Abstract

The role of extrachromosomal DNA (ecDNA) in lung cancer, particularly in subjects who never smoked (LCINS), remains unclear. Examination of over 1200 whole-genome-sequenced lung cancers identified ecDNA in 18.9% of patients. Recurrent amplification of MDM2 and other oncogenes via ecDNA possibly drives a LCINS subset. Tumors harboring ecDNA showed worse overall survival than tumors harboring other focal amplifications. A strong association with whole-genome doubling suggests most ecDNA reflects genomic instability in treatment-naïve lung cancer.

Identifiers

PMID42554978
PMCPMC13449186

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.