Evidence map›Paper›PMID 42554946›Full record

ArticleAdvances in therapy2026

Treatment Strategies in Incident and Recurrent Hyperkalemia: Insights from the TRACK Study.

Pietro Manuel Ferraro, Nitin Shivappa, Ameet Bakhai, Jordi Bover, Javed Butler, Linda Fried, Markus P Schneider, Navdeep Tangri, Wolfgang C Winkelmayer, Meredith Bishop and 7 more

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Article in Advances in therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Pietro Manuel FerraroSection of Nephrology, Department of Medicine, Università degli Studi di Verona, Piazzale L.A. Scuro 10, 37134, Verona, Italy. pietromanuel.ferraro@univr.it.
Nitin ShivappaAstraZeneca Pharmaceuticals LP, Wilmington, DE, USA.
Ameet BakhaiBarnet General Hospital, Royal Free London NHS Foundation Trust, Barnet, UK.
Jordi BoverNephrology Department, REMAR-IGTP and RICORS2040 Network, University Hospital Germans Trias I Pujol, Barcelona, Spain.
Javed ButlerBaylor Scott & White Research Institute, Dallas, TX, USA.
Linda FriedRenal Section, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA.
Markus P SchneiderDepartment of Nephrology and Hypertension, University Hospital Erlangen, Erlangen, Germany.
Navdeep TangriChronic Disease Innovation Center, University of Manitoba, Winnipeg, Canada.
Wolfgang C WinkelmayerSection of Nephrology, Baylor College of Medicine, Houston, TX, USA.
Meredith BishopAstraZeneca Pharmaceuticals LP, Wilmington, DE, USA.
Hungta ChenAstraZeneca Pharmaceuticals LP, Wilmington, DE, USA.
Anna-Karin SundinBioPharmaceuticals Medical, AstraZeneca, Gothenburg, Sweden.
Lovisa FribergBioPharmaceuticals Medical, AstraZeneca, Gothenburg, Sweden.
Julian ChenCPC Clinical Research, Aurora, CO, USA.
Xiaoting ChenCPC Clinical Research, Aurora, CO, USA.
Marc BonacaCPC Clinical Research, Aurora, CO, USA.
Judith HsiaCPC Clinical Research, Aurora, CO, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLittle is known about the implementation of guideline recommendations and healthcare provider decision-making when managing hyperkalemia. We aimed to address these knowledge gaps and better understand hyperkalemia management in routine clinical care and the baseline characteristics and longitudinal (12-month) clinical variables of participants with hyperkalemia.

methodsThis was an observational, prospective, longitudinal, cohort study including adults with recent (≤ 21 days of enrollment) hyperkalemia (serum potassium [K

resultsIn total, 1330 participants with hyperkalemia were included (458 incident, 870 recurrent). The most common treatment rationale for index hyperkalemia was ease of treatment (41.4%). Overall, 80.9% of participants received conservative treatment (no hyperkalemia treatment, monitoring K

conclusionsGuideline recommendations for incident and recurrent hyperkalemia were inconsistently implemented in clinical practice, as demonstrated by a conservative approach to treatment. Unmet hyperkalemia treatment goals and recurrent hyperkalemia were common.

Indexed as

Chronic kidney diseaseClinical studyDecision-makingGuideline-directed medical therapyHyperkalemiaPotassium

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.