ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2026
Lytic activity of F8-like phage φSPM-1 against One Health lineages of carbapenem-resistant Pseudomonas aeruginosa.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The increasing resistance of Pseudomonas aeruginosa to carbapenem antibiotics is shifting the landscape of high-risk clones from a strictly hospital-acquired threat to a global pathogen with One Health relevance. Given the limited therapeutic options available, developing new treatments is essential. We previously reported the complete genome sequence of φSPM-1 phage from the family Myoviridae. In this study, we show that φSPM-1 displays lytic activity against hospital and environmental metallo-β-lactamase (MβL)-producing P. aeruginosa and confers a protective effect against lethal infection caused by the high-risk clone ST277 in a Galleria mellonella prophylactic model.
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