Evidence map›Paper›PMID 42554893›Full record

ReviewCurrent pain and headache reports2026

Post-Craniotomy Headache: Current Concepts and Emerging Procedural Therapies.

Sarah A Friedman, Arathi Nandyala

Abstract readReview
In one paragraph

Review in Current pain and headache reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sarah A FriedmanDepartment of Neurology, Weill Cornell Medicine, 1305 York Ave, New York, NY, 10021, USA.
Arathi NandyalaDepartment of Neurology, Weill Cornell Medicine, 1305 York Ave, New York, NY, 10021, USA. asn4004@med.cornell.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewPost-craniotomy headache (PCH) is a common complication following neurosurgery, yet there remains limited consensus regarding the mechanism, classification, and optimal management. This review summarizes the current literature and highlights recent trends in procedural therapies. RECENT

findingsPCH occurs in approximately 60-70% of patients following craniotomy, with nearly 25% progression to persistent PCH. Identified risk factors include younger age, female sex, pre-existing headache disorders, and longer operative duration. Some studies further characterize PCH into migrainous, tension-type, cervicogenic, or neuropathic phenotypes, however classification remains inconsistent across the literature. Pharmacological treatment largely extrapolates from migraine and neuropathic pain management, though emerging evidence in the last few years supports the potential role of onabotulinumtoxinA and nerve blocks. Current evidence supports the use of pharmacological, nonpharmacological, and procedural interventions to treat PCH. Future research should prioritize a phenotype-driven approach, evaluation of standardized multi-modal protocols, as well as novel therapies, including calcitonin gene-related peptide (CGRP)-targeted agents.

Indexed as

CraniotomyHeadachePostoperative ComplicationsBotulinum Toxins, Type AFemaleHumansBotulinum Toxins, Type APersistent post-craniotomy headachePost-craniotomy headachePost-craniotomy pain

Identifiers

PMID42554893
PMCPMC13442312

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.